2016 Section 5 Green Book

Orlandi RR, Smith TL, Marple BF, et al. Update on evidence-based reviews with recommendations in adult chronic rhinosinusitis. Int Forum Allergy Rhinol . 2014; 4 Suppl 1: S1-S15. EBM level NA...............................................................................32-46 Summary : Orlandi et al present expert panel guidelines based on a systematic literature review. This review synthesizes the findings of eight evidence-based reviews with recommendations regarding chronic rhinosinusitis published in the International Forum of Allergy and Rhinology between 2011 and 2014. Subtypes of CRS Han JK. Subclassification of chronic rhinosinusitis. Laryngoscope . 2013; 123 Suppl 2:S15-S27. EBM level 2b...........................................................................................47-59 Summary : This article presents a working classification of the common clinical subtypes of chronic rhinosinusitis (CRS). The author presents a clinical and laboratory work-up to subtype CRS. Role of innate and adaptive immunity Adappa ND, Zhang Z, Palmer JN, et al. The bitter taste receptor T2R38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery. Int Forum Allergy Rhinol . 2014; 4(1):3-7. EBM level NA..................................60-64 Summary : Adappa et al studied tissue of chronic rhinosinusitis (CRS) patients undergoing primary functional endoscopic sinus surgery. The tissue was studied for genotype TAS2R38 . The TAS2R38 genotype was found to be an independent risk factor for CRS patients who failed medical therapy and required surgical intervention. Summary : This review focuses on both endogenous predisposing factors and exogenous triggers that may contribute to chronic upper airway disease and can also impact lower airway disease. Oakley GM, Curtin K, Orb Q, et al. Familial risk of chronic rhinosinusitis with and without nasal polyposis: genetics or environment. Int Forum Allergy Rhinol . 2015; 5(4):276-282. EBM level 3....................................................................71-77 Summary : This study used an extensive genealogical database from the state of Utah and linked medical records to study the risk of chronic rhinosinusitis with nasal polyps (CRSwNP) and without polyps (CRSsNP) in relatives and spouses of adult probands (1638 CRSwNP and 24,200 CRSsNP patients). These were compared to random population controls matched 5:1 on gender and birth year. Pathophysiology of CRS i. Hox V, Maes T, Huvenne W, et al. A chest physician's guide to mechanisms of sinonasal disease. Thorax . 2015; 70(4):353-358. EBM level 4.....................65-70

c.

2. Pathophysiology a.

ii.

Microbiome

b. Pathophysiology of tumors Tajudeen BA, Arshi A, Suh JD, et al. Importance of tumor grade in

esthesioneuroblastoma survival: a population-based analysis. JAMA Otolaryngol Head Neck Surg . 2014; 140(12):1124-1129. EBM level NA.............................................78-83

Summary : This article is a population database review presenting tumor-related outcomes and the impact of tumor grade/adjuvant radiation therapy on outcomes.