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TABLE 6. Nasal resistance (Pa/cm 3 /second) as measured by anterior rhinomanometry

Group 1 (antibiotics 24 weeks)

Group 2 (antibiotics 12 weeks) 2.09 ± 1.2 0.23 ± 0.03 0.19 ± 0.02 0.19 ± 0.02 *

Group 3 (control no antibiotic) 2.25 ± 1.00 0.26 ± 0.06 0.22 ± 0.03 1.94 ± 1.50

Visits

Baseline

4.22 ± 2.11 0.23 ± 0.03 0.19 ± 0.01 0.23 ± 0.02 *

6 weeks

12 weeks

24 weeks

*Significant differences between study and control groups ( p < 0.05).

TABLE 7. Total nasal cavity volume (cm 3 ) as measured by acoustic rhinometry

Group 1 (antibiotics 24 weeks)

Group 2 (antibiotics 12 weeks)

Group 3 (control no antibiotic) 9.97 ± 2.33 14.29 ± 1.55 16.33 ± 3.73 13.59 ± 2.82

FIGURE 3. Evaluation of CT scores, mean scores according to Lund-Mackay scale (* p < 0.05). CT = computed tomography.

Visits

TABLE 8. Lund-Mackay CT score evaluation (points)

Baseline

8.53 ± 1.20 17.35 ± 2.74 17.62 ± 2.79 16.74 ± 1.96

9.00 ± 1.69 15.58 ± 1.77 15.27 ± 2.27 14.68 ± 2.06

6 weeks

Group 1 (antibiotics 24 weeks)

Group 2 (antibiotics 12 weeks)

Group 3 (control no antibiotic)

12 weeks

Visits

24 weeks

Baseline

21.68 ± 1.19 9.71 ± 2.21 *

21.84 ± 1.66 12.62 ± 4.15

21.20 ± 1.57 16.66 ± 2.32

24 weeks

(antibiotics for 24 weeks) and group 2 (antibiotics for 12 weeks) was significantly lower (better breathing) (0.23 ± 0.02 and 0.19 ± 0.02 Pa/cm 3 /second, respec- tively) than in group 3 (control no antibiotics) (1.94 ± 1.50 Pa/cm 3 /second) at endpoint (Tables 6 and 7). CT scans Before initiation of treatment, mean values for the Lund- Mackay score in the first, second, and third patient groups did not differ significantly, being 21.68 ± 1.20, 21.84 ± 1.66, and 21.2 ± 1.57, respectively. The mean score of paranasal sinus opacification on CT scans dramatically de- creased (improved) in all 3 groups 6 months after FESS. However, a significant difference was observed only be- tween group 1 (antibiotics for 24 weeks) with a mean score of 9.71 ± 2.21, and group 3 (control no antibiotics) with a mean score of 16.66 ± 2.32 ( p < 0.05). In group 2 (antibi- otics for 12 weeks) the mean score was 12.62 ± 4.15, but this difference did not reach statistical significance (Fig. 3, Table 8). Nasal endoscopy Patients on clarithromycin therapy in group 1 (antibiotics for 24 weeks) and group 2 (antibiotics for 12 weeks) showed better EAS at each visit when compared to patients in group 3 who did not take antibiotics (Fig. 4, Table 9). Twenty-four weeks after surgery mean EAS were: 1.52 ± 0.87 in group 1 (antibiotics for 24 weeks) and 2.42 ± 1.61 in group 2 (antibiotics for 12 weeks), and these results were

*Significant differences between study and control groups ( p < 0.05). CT = computed tomography.

FIGURE 4. Evaluation of endoscopic findings in the nasal cavity calculated according to Endoscopic Appearance Score (* p < 0.05).

significantly better than group 3 (control no antibiotics) 6.35 ± 1.58 ( p < 0.05) (Fig. 4, Table 9). One of the most impressive cases demonstrating efficacy of postoperative long-term macrolide therapy is presented in Figure 5.

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