2016 Section 5 Green Book

Characteristics of Included Studies by Endoscopic Reconstruction Type (Free Grafting). Study Year Study Focus, Flap or Pathology No. Radiotherapy, % Batra 16 2010 Mixed benign and malignant neoplasms 31 17 Free 57.5 (14–84) 42 16 mm F, E, P 47 19 Cavallo 18 2007 Suprasellar: Men, CP, AD, RC, glioma 21 21 Free NR NR NR P 5 (7) 5 Chen 20 2006 Mixed malignant neoplasms 7 1 Free 52.7 (33–79) 29 NR E, P NR NR Church 21 2003 Iatrogenic post-ESS defects 3 3 Free 43.7 (10.6) 0 > 20 mm E, P 67 0 de Divitiis 23 2007 Suprasellar: Men, CP, AD, RC, AC 20 20 Free 49.5 (24–70) 55 NR P 15 NR de Divitiis 22 2007 Craniopharyngioma 10 10 Free 57.2 (26–70) 40 52.8 mm 2 P NR NR de Divitiis 24 2007 Meningioma 6 6 Free 56.1 (44–70) 50 24.7 mm P 0 0 El-Banhawy 27 2008 Meningioma (from mixed group) 3 3 Free 42.5 (40–45) 0 14 mm E, P NR NR Esposito 9 2007 Mixed: Men, CP, AD, Ch, RC, malignant neoplasms 620 58 Free 46 (5–86) 59 NR P, C 100 NR Gardner 1 2008 Meningioma 35 35 Free 55 (39–79) 83 NR E, P 100 6 Germani 32 2007 Mixed benign and malignant neoplasms, CSF leak 56 55 Free NR NR 29% 4–20 mm, 29% > 20 mm E, P 20 NR No. With Defect Repair Type Age (SD or Range) % Female Defect Size (Longest Axis) Defect Location Lumbar Drain Use, % (Days) Prior

Leng 39 2008 Mixed: Men, CP, Ch, CSF leak 10 10 Free NR NR NR E, P, C 50 10 Leong 40 2006 Mixed benign and malignant neoplasms 14 10 Free 57.4 (26–84) 43 4–40 mm E, P 70 (5) 29

Luginbuhl 41 2010 Control patients: free grafts 24 24 Free NR NR 17 mm E, P, C 33 NR Stamm 46 2008 Craniopharyngioma: free grafts 3 3 Free 23.4 (16.3) 33 NR P 0 NR Vergez 47 2009 Adenocarcinoma 17 5 Free 68 (44–82) 0 NR C, P NR NR Villaret 48 2010 Mixed malignant neoplasms 62 14 Free 61.7 (25–84) 29 NR E, P 47 19 F ¼ transfrontal; E ¼ transethmoid/cribriform; P ¼ transplanum; CP ¼ craniopharyngioma; AD ¼ adenoma; RC ¼ Rathke’s cyst;, NR ¼ not reported; ESS ¼ endoscopic sinus surgery; AC ¼ astrocytoma; Ch ¼ chordoma; C ¼ transclival; CSF ¼ cerebrospinal fluid; Men ¼ meningioma.

Horiguchi 35 2010 Control patients: free grafts 11 10 Free 52 (27–79) 27 NR E, P, C 90 NR Kassam 36 2007 Mixed benign and malignant neoplasms, CSF leak 25 11 Free 11.9 (5.3) 52 NR E, P, C NR NR Laufer 38 2007 Suprasellar: Men, CP, RC 10 10 Free 54 (12.4) NR 26.5 mm P 50 NR

TABLE III.

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