2017 Sec 1 Green Book

and November 2012 to capture re- cently published studies. The com- plete results of the literature review are published separately in the tech- nical report. 6 In summary, 17 ran- domized studies of sinusitis in children were identi fi ed and reviewed. Only 3 trials met inclusion criteria. Because of signi fi cant heterogeneity among these studies, formal meta- analyses were not pursued. The results from the literature review were used to guide development of the key action statements included in this document. These action statements were generated by using BRIDGE-Wiz (Building Recommendations in a Devel- opers Guideline Editor, Yale School of Medicine, New Haven, CT), an interactive software tool that leads guideline de- velopment through a series of ques- tions that are intended to create a more actionable set of key action statements. 7 BRIDGE-Wiz also incorporates the quality of available evidence into the fi nal de- termination of the strength of each recommendation. The AAP policy statement “ Classifying Recommendations for Clinical Practice Guidelines ” was followed in designating

levels of recommendations (Fig 1). 8 De fi nitions of evidence-based state- ments are provided in Table 1. This guideline was reviewed by multiple groups in the AAP and 2 external organizations. Comments were com- piled and reviewed by the subcom- mittee, and relevant changes were incorporated into the guideline.

Persistent illness, ie, nasal dis- charge (of any quality) or daytime cough or both lasting more than 10 days without improvement; OR Worsening course, ie, worsen- ing or new onset of nasal dis- charge, daytime cough, or fever after initial improvement; OR Severe onset, ie, concurrent fe- ver (temperature ≥ 39°C/102.2°F) and purulent nasal discharge for at least 3 consecutive days (Evi- dence Quality: B; Recommenda- tion).

KEY ACTION STATEMENTS Key Action Statement 1

Clinicians should make a pre- sumptive diagnosis of acute bacterial sinusitis when a child with an acute URI presents with the following:

KAS Pro fi le 1

Aggregate evidence quality: B Bene fi t

Diagnosis allows decisions regarding management to be made. Children likely to bene fi t from antimicrobial therapy will be identi fi ed. Inappropriate diagnosis may lead to unnecessary treatment. A missed diagnosis may lead to persistent infection or complications Inappropriate diagnosis may lead to unnecessary cost of antibiotics. A missed diagnosis leads to cost of persistent illness (loss of time from school and work) or cost of caring for complications.

Harm

Cost

Bene fi ts-harm assessment

Preponderance of bene fi t.

Value judgments

None.

Role of patient preference

Limited.

Intentional vagueness

None.

Children aged < 1 year or older than 18 years and with underlying conditions.

Exclusions

Strength

Recommendation.

TABLE 1 Guideline De fi nitions for Evidence-Based Statements Statement De fi nition

Implication

Strong recommendation A strong recommendation in favor of a particular action is made when the anticipated bene fi ts of the recommended intervention clearly exceed the harms (as a strong recommendation against an action is made when the

Clinicians should follow a strong recommendation unless a clear and compelling rationale for an alternative approach is present.

anticipated harms clearly exceed the bene fi ts) and the quality of the supporting evidence is excellent. In some clearly identi fi ed circumstances, strong recommendations may be made when high-quality evidence is impossible to obtain and the anticipated bene fi ts strongly outweigh the harms. A recommendation in favor of a particular action is made when the anticipated bene fi ts exceed the harms but the quality of evidence is not as strong. Again, in some clearly identi fi ed circumstances, recommendations may be made when high- quality evidence is impossible to obtain but the anticipated bene fi ts outweigh the harms. Options de fi ne courses that may be taken when either the quality of evidence is suspect or carefully performed studies have shown little clear advantage to one approach over another. No recommendation indicates that there is a lack of pertinent published evidence and that the anticipated balance of bene fi ts and harms is presently unclear.

Recommendation

Clinicians would be prudent to follow a recommendation, but should remain alert to new information and sensitive to patient preferences.

Option

Clinicians should consider the option in their decision-making, and patient preference may have a substantial role.

No recommendation

Clinicians should be alert to new published evidence that clari fi es the balance of bene fi t versus harm.

FROM THE AMERICAN ACADEMY OF PEDIATRICS

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