2017 Section 7 Green Book

Papagerakis et al.

OS univariate OS Multivariable Recur univariate Recur multivariable PPI Usage Yes 0.55 (0.42 – 0.73) 0.55 (0.40 – 0.74) 0.83 (0.60 – 1.14) 0.71 (0.50 – 1.01) No Ref. Ref. Ref. Ref. P < 0.0001 < 0.0001 0.39 0.06 Gender Male 1.14 (0.82 – 1.59) 1.30 (0.90 – 1.88) 1.09 (0.74 – 1.61) 0.94 (0.62 – 1.42) Female Ref. Ref. Ref. Ref. P 0.42 0.16 0.68 0.75 Primary tumor site OC 1.43 (1.02 – 2.00) 2.44 (1.50 – 3.96) 1.26 (0.84 – 1.87) 1.90 (1.12 – 3.23) HP, LAR 1.43 (0.99 – 2.06) 1.43 (0.94 – 2.18) 1.35 (0.90 – 2.02) 1.45 (0.92 – 2.29) NP, other, unknown 0.86 (0.50 – 1.47) 1.11 (0.62 – 2.00) 0.73 (0.38 – 1.43) 1.03 (0.50 – 2.13) OP Ref. Ref. Ref. Ref. P 0.05 0.004 0.22 0.08 Stage Late 1.65 (1.09 – 2.49) 1.59 (0.97 – 2.60) 1.79 (1.10 – 2.94) 1.14 (0.65 – 1.98) Early Ref. Ref. Ref. Ref. P 0.02 0.07 0.02 0.65 Smoking status Never 0.44 (0.30 – 0.66) 0.51 (0.33 – 0.79) 0.42 (0.26 – 0.67) 0.48 (0.29 – 0.79) Former 0.72 (0.53 – 0.98) 0.62 (0.44 – 0.88) 0.80 (0.57 – 1.14) 0.73 (0.49 – 1.07) Current-quit within 1 month Ref. Ref. Ref. Ref. P 0.0002 0.003 0.002 0.01 Education some college HS or less Ref. Ref. Ref. Ref. Some college or more 0.72 (0.54 – 0.96) 0.83 (0.61 – 1.13) 0.78 (0.56 – 1.09) 0.92 (0.64 – 1.31) P 0.02 0.24 0.14 0.64 30,000 or below 1.61 (1.05 – 2.47) 1.16 (0.71 – 1.90) 1.70 (1.05 – 2.75) 1.36 (0.79 – 2.33) Above 30,000 Ref. Ref. Ref. Ref. P 0.03 0.55 0.03 0.27 Treatment Surgery only 0. 56 (0.33 – 0.96) 0.39 (0.20 – 0.78) 0.16 (0.06 – 0.44) 0.12 (0.04 – 0.35) Radiation þ chemotherapy 1.05 (0.76 – 1.45) 0.96 (0.66 – 1.39) 0.71 (0.50 – 1.01) 0.75 (0.50 – 1.12) Age, y 10-year increase 1.43 (1.26 – 1.62) 1.60 (1.38 – 1.86) 1.02 (1.01 – 1.04) 1.03 (1.01 – 1.05) P < 0.0001 < 0.0001 0.006 0.0004 NOTE: OS and time to recurrence were analyzed using log-rank for univariate analysis and Cox proportional hazards models for multivariate analysis. All statistical analyses were done in SAS version 9.2 (SAS Institute). A two-tailed P 0.05 or less was considered statistically signi fi cant. HR followed by the 95% CI values between parentheses are provided. Abbreviations: HP, hypopharynx; HS, high school; LA, larynx; NP, nasopharynx; OC, oral cavity, OP, oropharynx; Recur, time to recurrence. Radiation þ chemotherapy þ surgery Ref. Ref. Ref. Ref. P 0.03 0.009 0.0004 < 0.0001 Radiation only 0.26 (0.08 – 0.83) 0.22 (0.06 – 0.74) 0.08 (0.01 – 0.55) 0.07 (0.01 – 0.51) Surgery þ radiation 1.13 (0.74 – 1.73) 0.56 (0.34 – 0.93) 0.67 (0.40 – 1.25) 0.44 (0.24 – 0.80) County median income from census H2RA Usage Yes 0.74 (0.55 – 1.00) 0.67 (0.47 – 0.95) 1.02 (0.73 – 1.42) 0.90 (0.61 – 1.34) No Ref. Ref. Ref. Ref. P 0.0479 0.02 0.92 0.61

Characteristics

Table 4. PPI and H2RA usage and patient OS and time to recurrence

Cancer Prevention Research

Cancer Prev Res; 7(12) December 2014

196