2018 Section 5 - Rhinology and Allergic Disorders

Medical management of AFRS

effects Conclusion

None reported Postoperative oral

itraconazole resulted in a more favorable

but not statistically

significant mucosal

stage compared to

the other 2 groups.

side

Complications/

Kupferberg et al. 15 )

clinical

Primary

end points

Endoscopic staging system (by

(dosage varied with age) + nasal

microgram twice daily in each nostril + nasal

protocol

Treatment

group: 200 mg twice daily

douches for 2 months.

2. Topical steroid group: topical

budesonide 100

douche for 4 months.

3. Nasal douches group: alkaline

saline douches for 6 months.

1. Itraconazole

3. Nasal douches only (n = 11).

1. Oral itraconazole (n = 11).

2. Topical steroids (n = 12).

Study

groups

1b 34 Postoperative AFRS patients:

Subjects (n)

TABLE 4. Topical nasal steroids in postoperative AFRS summary Level of evidence

AFRS = allergic fungal rhinosinusitis; IgE = immunoglobulin E; RCT = randomized controlled trial.

Bent and

Kuhn criteria

(not all patients

underwent IgE

testing. Total IgE

was elevated in

19/20 patients and

fungal-specific IgE was

elevated in

15/17 patients).

Gupta et al. 36 2007 RCT Partially fulfilled

Study

design

Study authors Year

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