2018-19 Section 7-Neoplastic and Inflammatory Diseases of the Head and Neck eBook

Lymph Node Staging for Salivary Cancer/Aro et al

TABLE 1. Univariate and Multivariable Predictors of OS for Patients With Salivary Gland Malignancies Under- going Surgery and Neck Dissection Using Cox Regression

Univariate Survival Analysis

Multivariable Survival Analysis

Characteristics

HR

95% CI

P

HR

95% CI

P

No. of positive metastatic LNs a

- -

- -

- -

< .001

- -

- -

- -

< .001

No. of LNs examined a

.978

.007

Age Sex

1.039

1.036

1.043

< .001

1.026

1.021

1.032

< .001

b

Male

1.000 0.612

-

-

-

Female

0.551

0.680

< .001

Race

White Black Other

1.000 0.843 0.597 1.000 1.408 2.077

-

-

-

1.000 1.091 0.733 1.000 1.131 1.711

-

-

-

0.707 0.460

1.006 0.774

.058

0.911 0.563

1.308 0.954

.344 .021

< .001

Charlson-Deyo Comorbidity Index 0

-

-

-

-

-

-

1

1.232 1.667

1.608 2.589

< .001 < .001

0.986 1.363

1.296 2.146

.078

2

< .001

Facility type

Nonacademic center

1.000 0.822

-

-

-

Academic center

0.744

0.908

< .001

0.864

0.778

0.959

.006

Facility volume Low

b

1.000 0.772

-

-

-

High

0.698

0.853

< .001

Insurance

Uninsured

1.000 0.779 1.012 1.904 0.977 0.997 1.000 0.985 0.660 0.807 1.000 1.511 0.909 1.666 0.749 1.529 1.000 2.177 6.165 1.000 2.193 3.524 4.626 1.000 1.998 1.883

-

-

-

1.000 0.675 0.952 0.827 0.656

-

-

-

Private

0.570 0.696 1.396 0.657 0.977

1.067 1.473 2.596 1.454 1.017

.119 .948

0.491 0.652 0.594 0.436

0.929 1.389 1.152 0.987

.016 .797 .261 .043

Medicaid Medicare

< .001

Other/unknown

.911 .772

b

Y of diagnosis Anatomic site

b

Parotid gland

-

-

-

Submandibular or sublingual gland

0.851 0.538 0.658

1.141 0.810 0.989

.845

Oral cavity

< .001

Other head and neck sites Histology Mucoepidermoid carcinoma

.039

-

-

-

1.000 0.863 1.277 0.727 1.344 0.901

-

-

-

Adenocarcinoma

1.332 0.773 1.315 0.598 1.273

1.714 1.069 2.112 0.938 1.837

< .001

0.758 1.078 0.571 1.068 0.746

0.984 1.514 0.927 1.690 1.087

.028 .005 .010 .012 .274

Adenoid cystic carcinoma Salivary duct carcinoma

.250

< .001

Acinic cell carcinoma

.012

Other carcinoma, including ex-pleomorphic adenoma

< .001

Grade c Low

d

-

-

-

Intermediate

1.695 4.929

2.797 7.710

< .001 < .001

High

T classification T1

-

-

-

1.000 1.615 2.039 2.647

-

-

-

T2 T3 T4

1.814 2.936 3.877

2.651 4.229 5.519

< .001 < .001 < .001

1.331 1.687 2.199

1.960 2.465 3.187

< .001 < .001 < .001

Metastatic LN size, cm c 0-3

b

-

-

-

3.1-6

1.740 1.364

2.295 2.601

< .001 < .001

> 6

Lower LN involvement c No

1.000 3.434

-

-

-

1.000 1.134

-

-

-

Yes

3.066

3.846

< .001

0.978

1.316

.096

Contralateral LN involvement No

b

1.000 2.241

-

-

-

Yes

1.671

3.005

< .001

ENE c

b

Negative ENE Positive ENE

1.000 3.049

-

-

-

2.745

3.388

< .001

Cancer

3