2018-19 Section 7-Neoplastic and Inflammatory Diseases of the Head and Neck eBook
C.
Sua´rez
et
al.
/ Auris Nasus
Larynx
43
(2016)
477–484
Table 2 Distribution
of
adenoid
cystic
carcinomas
of
the
head
and
neck.
Minor glands
Oral
salivary
salivary
cavity
(%)
Oropharynx (%)
Sinonasal
(%)
Others
(%)
No.
Major glands
(%)
(%)
et
al.
[6]
2286
1117
(48.9)
995
(43.5)
618
(27) (24) (28) (50)
43 12
(1.9)
308
(12.5)
200
(8.7)
Lloyd Chen
et
al.
[7]
140
55 18
(39) (31) (29)
85 41
(61) (39) (71)
33 17
(9)
28 13 68
(20) (22) (15) (6.5)
12
(9) (8) (1)
et
al.
[8]
59
6
(10)
5 6 –
Gomez
et
al.
[9]
457
133
324
227
23
(5)
Amit
et
al.
[10]
61 76
30
(49.2)
31
(50.8)
27 49
(44.3) (64.5) (54.3) (15.2) c (26.2) (41.9) (41.2) c (16.2)
–
4
Lee
[11] a
et
al.
27 52
(35.5)
Agarwal
et
al.
[12]
616
194
(31.5) (41.4) (26.2) (37.2) (26.2) (44.8)
422
(68.5) (58.6) (72.8) (62.8) (73.8) (55.2)
335
(8.4)
60 35
(9.7)
27
(4.4) (8.1) (19) (1.5)
Min
et
al.
[13]
99 42
41 11 48 42 47 24
58 31 81 58 96 41
15 11 54 66 17 38 28
(35.3) (16.7)
8 8 2
Oplatek
et
al.
[14]
5 3
(11.9)
7
Ko
Perez
et
al.
[15]
129 160 105 120
(2.3)
22 29
(17)
da Cruz Fordice
et
al.
[16]
118
(18.1)
23
(14.4)
et
al.
[17]
28 13
(26.7)
8
(7.6) (20)
4
(3.8)
van Weert Balamucki Anderson
et
al.
[18]
(20)
(80)
(31)
(11) (2.4)
24
16
(13.3)
[19] b
et
al.
41
(68.3)
1
8
(19.5)
4
(9.7)
a Only b Only
includes
intraoral
tumors.
includes minor
salivary
gland
tumors.
c Includes
oral
cavity
and
oropharyngeal
tumors
all
together.
AdCC
occurs
more
often
in
the
minor
salivary
glands found
these
two
events
and
accordingly,
the
term
distinguish between
than
in
the
major
glands
(20–49%),
and
is
as
applied
to
cervical
lymph
nodes
in
this
paper
(43–80%)
‘‘metastasis’’
in
the
oral
cavity, ( Table
followed
by
sinonasal
tract
and
both
possibilities
unless
stated
otherwise. uncommon succumbing
Although
mainly
includes
[6–19]
2 ).
The
most
frequent
intraoral
long-term
prognosis
is
poor,
it
is
not
for
some their some
oropharynx
the
is
the
palate,
followed
by
the
buccal mucosa
and
the
to
survive
10–15
years
before
to
subsite floor of
patients
the mouth
[11,12,20,21] .
In
the oropharynx,
the base of
late
local
and distant
recurrences
appear with
disease. As frequency,
tongue
and
the
soft
palate
are
the most
frequently
involved
long-term
follow-up
is
necessary
to
assess
the
the
sites
effectiveness of
[11,12,15,20]
( Table
3 ).
treatment. AdCC also has a high propensity for
natural
history
of AdCC
is
characterized recurrences;
by
slow,
but
invasion,
sometimes
associated
with
remotely
The
perineural occurring
growth;
multiple
local
and
distant
lesions
along
nerve
sheaths,
which
significantly
relentless
hematogenous dissemination mainly to the
lung, nodes
liver, bone and
the
risk
of
recurrence
after
resection,
even
when
increase
Involvement
of
regional
lymph
is
relatively
are
obtained.
brain.
negative margins
and
has
often
thought
to
be
the
result
of
direct
elective
neck
dissection
(END)
generally
has
not
uncommon extension of
Although
tumor
from an adjacent primary
tumor
site. Lymph
considered
indicated
in
treatment
of AdCC,
there
is
some
been
spread,
in
contrast,
has
been
considered
to
occur
on
its
potential
advantage
in
terms
of
a
reduction
of
node
debate
infrequently.
regional relative patient
In
practice,
it
is
often
difficult
or
impossible
to
recurrence
and
distant
spread.
However,
due
to
the
rarity
of
these
tumors,
most
studies
report
on
small
cohorts
over
extended locations
periods,
including
all
histologic
in
the head and neck,
thus making
types and at various
Table 3 Relative subsites.
difficult
to
draw
solid
conclusions
about
therapeutic
options.
it
localization
of
adenoid
cystic
carcinoma
by
oral/oropharyngeal
further
address
this
issue,
we
critically
reviewed
the
To
on
AdCC
of
the
oral
cavity
and
oropharynx
to
literature determine
Bianchi et al.
Min et
da
Cruz
Agarwal et al.
the
frequency guidelines
of
cervical
lymph
node
involvement be managed.
[11]
[20]
al.
[12]
Perez et al.
[15]
and On
to
suggest
on
how
the
neck
should
these
purposes,
we
undertook
a
search
of
the
English
No.
cases
76
67
335
54
cavity palate tongue
subsites
Oral Hard Oral
in
the PubMed database
(including Medline) using
the
literature
(49.5) a
22
(28.9)
48
(71.6)
166
29 10
(53.7) (18.5)
strategy
‘‘adenoid carcinoma
cystic
carcinoma
oropharynx’’,
search
3
(3.9)
3 3 6 2 3 2
(4.5) (4.5)
17 31 59 10
(5.1) (9.3)
cystic
oral
cavity’’,
and
‘‘adenoid
cystic
‘‘adenoid
13
(17.1) (11.8)
5 5 5
(9.3) (9.3) (9.3)
Buccal mucosa
excluded
case
reports,
series with
a
carcinoma head neck’’. We
of mouth
9 – –
(9) (3)
(17.6)
Floor
number
of
cases,
and
papers with
no
information
on
the
small neck
(3)
Lip
area
(4.5)
Retromolar
status
and/or
outcomes.
(3)
Alveolar mucosa –
subsites
Oropharynx
2.
Incidence
and
consequences
of
cervical
lymph
node
tongue
10 12
(13.2) (15.8)
52
(15.5)
Base Soft
metastasis
palate
(2.6) (3.9)
Tonsil
2 3
specified
3
(5.5)
Not
to
the
cervical
lymph
nodes
is
uncommon metastases
in at
Metastasis
a Includes
The
incidence
of
clinically
evident
AdCC.
hard
and
soft
palate.
28
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