FLEX November 2023

Patel et al.

Page 18

Event Neoadjuvant–Adjuvant Group Adjuvant-Only Group Grade 3 Grade 4 Grade 3 Grade 4 number of patients/total number Thromboembolic event 0 0 1/141 0 Wound dehiscence 1/127 0 0 0 Wound infection 1/127 0 0 0

Alanine aminotransferase level increased 2/113 0 2/131 0 Alkaline phosphatase level increased 1/113 0 0 0 Arthritis 0 0 1/131 0

Aspartate aminotransferase level increased 2/113 0 2/131 0 Blood or lymph disorder — other 0 0 1/131 0 Cardiac disorder — other 0 1/113 1/131 0 Cognitive disturbance 0 0 1/131 0 Dehydration 1/113 0 0 0 Diarrhea 0 0 1/131 0 Fatigue 0 0 2/131 0

Gallbladder infection 0 0 1/131 0 Headache 1/113 0 0 0

Hepatobiliary disorders — other 0 0 1/131 0 Hyperglycemia 0 0 2/131 0 Hypertension 0 0 1/131 0 Hypokalemia 1/113 0 0 0 Hyponatremia 1/113 0 0 0

Lung infection 0 1/113 0 0

Lymphocyte count decreased 1/113 0 2/131 0 Maculopapular rash 1/113 0 4/131 0

Metabolism or nutrition disorders — other 0 0 1/131 0 Nausea 2/113 0 0 0 Platelet count decreased 0 0 0 1/131 Pneumonitis 1/113 0 0 0 Pruritus 1/113 0 2/131 0

Author Manuscript Author Manuscript Author Manuscript Author Manuscript

Event attributed to adjuvant therapy

N Engl J Med . Author manuscript; available in PMC 2023 September 02.