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Wise et al.

Page 380

Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE IX.B.3.a.

Evidence for the role of oral decongestants in the management of allergic rhinitis Study Year LOE Study design Study groups Clinical endpoint Conclusion Salerno et al. 1324 2005 1a SR 1 Phenylpropanolamine; 2 Placebo SBP, DBP, HR Phenylpropanolamine caused increase in SBP. Salerno et al. 1325 2005 1a SR 1 Pseudoephedrine; 2 Placebo SBP, DBP, HR Pseudoephedrine caused increase in SBP and HR. Meltzer et al. 1323 2015 1b RCT 1 Phenylephrine 10 mg (n = 109); 2 Phenylephrine 20 mg (n = 108); 3 Phenylephrine 30 mg (n = 107); 4 Phenylephrine 40 mg (n = 112); 5 Placebo (n = 103) Daily reflective nasal congestion score Phenylephrine is not better than placebo at relieving nasal congestion. Horak et al. 1322 2009 1b RCT 1 Pseudoephedrine; 2 Phenylephrine; 3 Placebo Subjective evaluation of nasal congestion Mucha et al. 1321 2006 1b RCT 1 Pseudoephedrine; 2 Montelukast

Pseudoephedrine resulted in improvement in nasal congestion. Phenylephrine did not improve nasal congestion.

symptoms of AR, nPIF, and QOL with both pseudoephedrine and montelukast.

Children less than 2 years of age are at the highest risk for toxicity with pseudoephedrine. Safe dosing recommendations are lacking for this age group. Phenylpropanolamine is an independent risk factor for hemorrhagic stroke in women.

Kernan et al. 1326 2000 3b Case-control 1 History of subarachnoid or intracerebral hemorrhage; 2 Control Roberge et al. 1328 1999 4 Case report 2-year-old developed psychosis and ataxia after being overmedicated with pseudoephedrine/ dextromethorphan cough preparation. Sauder et al. 1329 1998 4 Case report 3-year-old with visual hallucinations caused by inappropriately high doses of pseudoephedrine. AR = allergic rhinitis; DBP = diastolic blood pressure; HR = heart rate; LOE = level of evidence; nPIF = nasal peak inspiratory flow; QOL = quality of life; RCT = randomized controlled trial; SBP = systolic blood pressure; SR = systematic review.

Nasal symptoms, nPIF, QOL Significant improvement from baseline in all Pseudoephedrine use in pediatric population Association between the use of phenylpropanolamine and the risk of a hemorrhagic stroke.

consecutive cohort

Vernacchio et al. 1327 2008 3b Non

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.