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Wise et al.

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Author Manuscript Author Manuscript Author Manuscript Author Manuscript Study design Study groups Clinical endpoint Conclusion

Improvement in symptoms and medication usage compared to placebo.

Significant reduction in median combined scores at year 2 compared to placebo.

Significantly improved combined scores in peak season at year 2 compared to placebo.

Pre-seasonal grass pollen allergoid resulted in significantly improved symptom and medication score compared to placebo.

Significant reduction in symptom and medication scores for both treatment groups compared to placebo.

High molecular weight and pollen extract were most effective, followed by unfractionated

allergoid. All better than placebo.

Significant elevations in blocking antibodies and decrease in symptoms scores in treatment group.

Significant elevations in blocking antibodies and decrease in symptoms scores in treatment group.

All doses above 20,000 AUeq/mL showed improved efficacy compared to placebo.

Combined symptom and

medication score, rescue medication use, total

rhinoconjunctivitis symptom score

Combined symptom and medication score

Combined symptom and medication score

Combined symptom and medication score

Symptom and medication scores during pollen season

Clinical symptoms: rhinitis, conjunctivitis, asthma

Blocking antibodies, daily symptom scores

IgE and blocking antibodies, daily symptom scores

Clinical response to a titrated nasal provocation test

Study Year LOE Allergoids/polymerized allergens Klimek et al. 1605 2014 1b DBPCT 1 Cluster immunotherapy with grass/rye polymerized antigen

Pfaar et al. 1594 2013 1b DBPCT 1 Mixed depigmented polymerized birch and grass pollen extract; 2 Placebo

Pfaar et al. 1593 2012 ib DBRCT 1 Pre-seasonal depigmented polymerized grass pollen SCIT; 2 Placebo

Corrigan et al. 1606 2005 1b DBPCT 1 Pre-seasonal grass pollen allergoid (low dose); 2 Pre-seasonal grass pollen allergoid (high dose); 3 Placebo Bousquet et al. 1607 1990 1b RDBPCT 1 Low-dose grass pollen allergoid; 2 High-dose grass pollen allergoid; 3 Placebo

Bousquet et al. 1608 1989 1b RDBPCT 1 Unfractionated grass pollen allergoid;

2 High molecular weight grass pollen allergoid; 3 Standardized grass pollen extract; 4 Placebo

Grammer et al. 1592 1983 1b RDBPCT 1 Pre-seasonal polymerized whole grass; 2 Placebo

Grammer et al. 1591 1982 1b DBPCT 1 Pre-seasonal polymerized ragweed; 2 Placebo 3 No treatment

Pfaar et al. 1609 2016 2b RCT 1 Mite allergoid SCIT 6667 AUeq/mL;

2 Mite allergoid SCIT 20,000 AUeq/mL;

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.