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Wise et al.

Page 421

Author Manuscript Author Manuscript Author Manuscript Author Manuscript Aggregate grade of evidence Direction of impact Magnitude of impact a Recommendation, considering: harm and cost

Strong recommendation b

Strong recommendation b

Strong recommendation b

Strong recommendation b

SLIT has a long-term effect beyond 3-years’ application B Yes Moderate evidence Recommendation LOE: Durham 2012 1705 2b, Didier 2015 1706 2b

SLIT with ragweed-pollen is effective for SAR A Yes Moderate effect LOE: Durham 2016, Nolte 2013, Creticos 2013, 1b (tablet ragweed); Creticos 2014 (drop ragweed); Skoner 2010 (drop ragweed) 1b SLIT with HDM is effective for AR A Yes Low impact LOE: Nolte 2015, Bergmann 2014, Mosbech 2015 all 1b; Calderon 2a SLIT with epithelia is effective for AR — No data No data Option No separate data in the systematic reviews/meta-analyses; no recent trials SLIT with fungi is effective for AR B Yes Weak evidence Option No separate data in the systematic reviews/meta-analyses. Cortellini 2010 1688 1b

SLIT with grass-pollen is effective for SAR A Yes Low impact LEO: Valovirta 2006 1683 1b

LOE: Di Bona (2 studies) 1a; Nelson 1b; Durham 1b. SLIT with tree-pollen is effective for SAR A Yes Moderate effect

Issue

a For those variables with meta-analysis: according to Cohen’s classification: low impact SMD 0.2-0.5, moderate 0.5-0.8, high above 0.8. For those with only systematic review: strength of evidence. b Considering the added long-term posttreatment effect and the possible preventive effects on the development of asthma and new sensitizations. AR = allergic rhinitis; INCS = intranasal corticosteroids; LOE = level of evidence; SAR = seasonal allergic rhinitis; SCIT = subcutaneous immunotherapy; SLIT = sublingual immunotherapy.

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.