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Wise et al.

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Author Manuscript Author Manuscript Author Manuscript Author Manuscript TABLE X.F.

Evidence for the association between allergic rhinitis and adenoid hypertrophy Study Year LOE Study design Study groups Clinical endpoint Conclusion Dogru et al. 1934 2017 4 Retrospective, cross sectional, nonrandomized 1 AR; 2 AR plus AH Symptoms, allergen sensitivities, allergy comorbidities The AR plus AH group had more severe symptoms than the group with AR alone. Atan Sahin et al. 1936 2016 4 Case-control Children from humid vs less humid locations AH, SPT, IgE, vitamin D High humidity group had higher prevalence of AH, higher IgE levels, and an association between AH and SPT for dust mite. Eren et al. 1941 2015 4 Consecutive cohort 155 children referred to Otolaryngology from Pediatric Allergy Nasal endoscopy and SPT There was a negative correlation between AH and SPT positivity ( r = −0.208, p = 0.009). Evicimk et al. 1933 2015 4 Retrospective, cross sectional, nonrandomized 1 AR; 2 NoAR AH, cigarette exposure, gender, age, family history of allergy, asthma, SPT AH was more prevalent in the AR group. Cigarette smoke exposure was associated with AH. Pagella et al. 1947 2015 4 Retrospective case series Otolaryngology clinic for nasal symptoms (1-7 years, n = 582; 8-14 years, n = 213) Allergy testing (n = 169), endoscopic adenoid size, clinical symptoms In the whole population: AH and AR not associated age 1-7 years ( p = 0.34), AH and AR associated with age in 8-year-old to 14-year-old group ( p = 0.0043). Ameli et al. 1939 2013 4 Consecutive cohort 205 children with persistent upper airway obstruction ( p < 0.001). tonsillar hypertrophy, allergy sensitivity Sadeghi-Shabestari et al. 1940 2011 4 Cohort 1 Adenotonsillar hypertrophy (n = 117); SPT for food, inhalant, and latex Modrzynski & Zawisza 1935 unblinded,

Adenotonsillar hypertrophy and positive SPT 70.3%. No adenotonsillar hypertrophy and positive SPT 10%. ( p = 0.04).

Negative correlation: SPT and tonsil hypertrophy. No correlation: SPT and AH.

Increased adenoid size in birch allergic children during pollen season, decreased after pollen

season, and prevented by allergy pharmacotherapy.

% with “allergy” decreased with increasing adenoid size. Statistical significance not calculated.

Nasal endoscopy and SPT Adenoid volume and % with no associated allergy Acoustic rhinometry, endoscopic adenoid exam Nasal endoscopy. “Allergic rhinitis was diagnosed by prick test and RAST in 22 patients” (20.9%)

2 No adenotonsillar hypertrophy (n = 100) 1 Tree-sensitive (n = 28);

2 Mugwort-sensitive (n = 14); 3 Nonatopic (n = 15);

4 Tree-sensitive “treated” (n = 10)

Karaca et al. 1938 2012 4 Case series Children with upper airway obstruction (n = 82) Radiographic AH, clinical 2007 4 Prospective controlled not specified)

Children with nasal obstruction (n = 98, age 3– 14 years)

Cassano et al. 1931 2003 4 Cohort (recruitment

Int Forum Allergy Rhinol . Author manuscript; available in PMC 2020 June 10.