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good” improvements, N ¼ 17 (24.3%) noted good improvements, and N ¼ 3 (4.3%) failed. Rhinorrhea: N ¼ 25 (continued)

Obstruction: N ¼ 44 (92%) noted com plete relief, N ¼ 4 (8%) noted less than 50% improvement. Drainage: N ¼ 16 (47%) noted complete relief. N ¼ 14

104 Subjective improvements in rhinorrhea, obstruc tion, and sneezing, and subjective overall improvements Improvements in rhinorrhea: N ¼ 66 (63.5%) cure rate, N ¼ 14 (13.5%) noted

moderate relief. Improvements in nasal obstruction: N ¼ 52 (63.4%) cure rate. Sneezing: N ¼ 28 (26.9%) cure rate. Overall response rate: N ¼ 42 (40.4%) noted great benefit, N ¼ 32 (30.8%) noted moderate benefit, N ¼ 20 (19.2%) noted little benefit, and N ¼ 10 (9.2%) noted no benefit

(41%) noted greater than 50% reduc tion, and N ¼ 4 (12%) noted less than 50% reduction Obstruction: N ¼ 50 (71.4%) noted “very

N Success Outcomes

N ¼ 18 (85.7%) noted substantive/subjec tive improvements in obstruction, rhinorrhea, or both

Mean TNSS for nonallergic: Total—base line: 6.5, 30 d: 2.6, 90 d: 2.4, 180 d: 1.7,

365 d: 1.6; rhinorrhea—baseline: 2.5, 30 d: 1.0, 90 d: 1.1, 180 d: 1.0, 365 d: 0.9; congestion—baseline: 2.0, 30 d: 0.8, 90 d: 0.6, 180 d: 0.4, and 365 d: 0.3

Mean TNSS for nonallergic: total—base line: 6.2, 30 d: 2.5, 90 d: 3.1, 180 d: 2.7,

365 d: 2.5; rhinorrhea—baseline: 2.2, 30 d: 1.0, 90 d: 1.3, 180 d: 1.1, 365 d: 1.7; congestion—baseline: 1.8, 30 d: 0.7, 90 d: 0.8, 180 d: 0.5, 365 d: 0.7

(35.7%) noted very good improvements,

Based on significant decrease in TNSS scores

Based on significant decrease in TNSS scores

Strome 16 Nonallergic rhinitis 1990 Frigitronics probe 21 Objective postoperative examination and sub jective classifications of complete resolution, improved, and no change

50 Subjective absence of obstruction or rhinorrhea

70 Subjective classifications of: very good, good, and failed

20 at 180 d and 15 at 365 d

20 at 180 d and 15 at 365 d

Posttreatment

Table 2. Outcomes of Cryotherapy in Allergic and Nonallergic Cohorts. Author Cohort Year Device Hwang et al. 32 Nonallergic rhinits 2017 ClariFix (nitrous oxide) Allergic rhinitis 2017 ClariFix (nitrous oxide)

044 (nitrous oxide)

(nitrous oxide)

(nitrous oxide)

Varshney and Chandra 15 Allergic rhinitis 1997 Basco-Cryos Model

Bumsted 17 Nonallergic rhinitis 1990 Krymed FT-300

Escapa Garrachon et al. 28 Nonallergic rhinitis 1990 Frigitronics CT-73

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