Quick Reference Guide to TNM Staging of Head and Neck Cancer and Neck Dissection Classification

Pathologic Stage Grouping for HPV-mediated Oropharyngeal Cancer Stage I T1 N0, N1 M0 T2 N0, N1 M0 Stage II T1, T2 N2 M0 T3, T4 N0, N1 M0 Stage III T3, T4 N2 M0 Stage IV Any T Stage Any T Stage M1 L. Group Staging for Unknown Primary Cancer of the Head and Neck, p16(-), Excludes EBV(+) Disease as Well as Thyroid Cancer and Melanoma* Group Staging for Unknown Primary Cancer of the Head and Neck Stage III T0 N1 M0 Stage IVA T0 N2 M0 Stage IVB T0 N3 M0 Stage IVC T0 Any N Stage M1 *Note: EBV(+) and p16(+) cervical lymph node metastases are classified as T0 and staged based on nasopharyngeal and HPV-mediated oropharyngeal cancer staging, respectively.

26 TNM Staging of Head and Neck Cancer and Neck Dissection Classification