September 2019 HSC Section 1 Congenital and Pediatric Problems

Follow-up (mo.) Results Conclusion

Intralesional cidofovir is a good treatment option with limited local and systemic effects

Surgical excision in combination with intralesional cidofovir is efficacious in AO-RRP; con- centration and interval

between injections influenced the number of injections

needed to achieve remission

Surgical excision in combination with intralesional cidofovir is efficacious; relapse associated with long delay in initiating cidofovir treatment

Treatment was well-tolerated and no immediate side effects were observed

Found to be efficacious in treat- ing RRP; more follow up is needed to analyze long-term effectiveness

Intralesional cidofovir reduced burden of disease in children with RRP; recurrent disease

may be treated with increased dosage

1 Derkay severity score decreased in all patients from a mean 6 SD of 13.7 6 6.0 to 2.1 6 3.4

Snoeck et al. 80 17 (16 AO/1 JO) 7.0 2.5 5 15 Complete remission in 14 (82.4%) patients, 13 AO and 1 JO (100%) patients Akst et al. 112 11 JO 4, if recurred an additional 4 5, if recurred 4, if recurred an additional 4

obtained in 17 (89%) patients; remission stable to a mean of 24 months follow-up

Naiman et al. and Coulombeau et al. 81–83 16 JO 8.9 5–7.5 2–4 weeks 33.6 Complete remission obtained in 12 (75%) patients; remission stable to a mean of 33.6 months follow-up

Lee et al. 113 16 (12 AO/4 JO) 3.5 2.5-5 3 weeks 25.4 Complete remission in 10 (77%) patients, 8 AO and 2 JO

Naiman et al. and Coulombeau et al. 81,82,84 19 AO 4.5 5–7.5 2–4 weeks 24 Complete remission was

Mean

Bielamowicz et al. 111 14 AO 6.0 4.17-6.25 12 Up to 3 years Complete remission in all 14 an additional 10

TABLE II.

Treatment (mo.)

Summary of Cidofovir in Reviewed Studies.

Mean

Concentration (mg/mL)

Mean No.

AO 5 adult-onset; JO 5 juvenile-onset; RRP 5 Recurrent respiratory papillomatosis

of Injections

Study Patients ( N )

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