September 2019 HSC Section 1 Congenital and Pediatric Problems

ZAMANI ET AL .

Study characteristics, with patient age, gender, and tumor site

TAB L E 1

Studies with all salivary glands and histopathology available

Mean/median age, years (range)

Authors (publication year, country) Rebours et al (2017, France)

Inclusion period

Cases, n a

Center/data source(s)

F:M ratio PG (%)

SMG (%)

MSG (%)

Six large Ile-de-France hospitals 1992–2012 43 - /13 (0–18)

1.26

86

4.7

9.3

Mao et al (2017, China)

Peking University Hospital

2002–2012 24 13.2/12.3 (5–16)

1.00

MEC only; 100% in the PG

Radomski et al (2017, USA)

Multicentric SEER database

2002–2013 245 14.5/15 (0–19) 1.45

Major glands only; 90% PG and 10% SMG

Locati et al (2017,

National Italian & Hamburg Pathology Databases Memorial Sloan Cancer Center, New York Tata Memorial Cancer Center, Bombay Mayo Clinic, Cancer Center, Minnesota

1996–2010 29 -/13 (4–18)

1.23

75.9

3.4

20.7

Italy and Germany)

Xu et al (2017, USA)

1992–2016 38 -/- (-)

–

55.3

10.5

34.2

Qureshi et al (2016, India) Cockerill et al (2016, USA)

2005–2014 24 -/12 (5–17)

1.25

66.7

16.7

16.7

1950–2005 56 14.1/- (3–18)

1.33

87.5

5.4

7.1

Fang et al (2013, China) b Deng et al (2013, China) b

China Medical University Hospital

1987–2011 17 14.3/- (1–18)

0.89

88.2

0

5.9

Nanjing University Hospital

1975–2011 32 15.1/- (2–19)

0.78

43.8

12.5

40.6

Liu et al (2012, China) Wuhan University Hospital

1990–2010 13 14.9/16 (1–18) 2.25

Only parotid glands

Aro et al (2012, Finland) Galer et al (2012, USA) Kupferman et al (2010, USA) Laikui et al (2008, China) Ellies et al (2006, Germany) Whatley et al (2006, USA) Ribeiro et al (2002, Brazil)

Multicentric University Hospitals Texas MD Anderson Cancer Center c Texas MD Anderson Cancer Center c

1992–2011 10 14.6/14 (9–19) 1.50

80

0

20

1952–2006 35 15.2/- (6–18)

1.19

Only minor glands

1953–2006 61 14.2/15 (3–18) 1.03

Only major glands; 84% PG and 16% SMG

Sichuan University Hospital

1992–2004 19 14.5/- (3–18)

0.73

47.4

15.8

36.8

Göttingen University Hospital

1966–2000 12 -/- (1–18)

3.00

100

0

0

St. Jude Children '

s Research

1963–2003 11 -/- (–)

–

81.8

9.1

9.1

Hospital

A.C. Camargo Cancer Hospital

1953–1997 27 12.1/12 (2–18) 1.45

74.1

7.4

18.5

Yu et al (2002, China) Peking University Hospital

1974–1999 46 -/- (3–16)

–

67.4

4.3

28.3

Hicks and Flaitz (2000, USA) Weighted average (95% CI)

Texas Children '

s Hospital

–

26 11/- (6–18)

2.71

Only cases of MEC; 61.5% PG, 30.8% SMG and 7.7%MSG

14.2 (14.1– 14.3)/14.2 (14.1–14.4) 20.7 (19.5– 21.9) SEER, Surveillance, Epidemiology and End Results, F:M, female to male; PG, parotid gland; SMG, submandibular gland; MSG, minor salivary gland; MEC, mucoepidermoid carcinoma; CI, confidence interval. a Only the number of malignant cases was included. b These studies were the only studies with sublingual gland cancer, one case each. c These studies were both from the MD Anderson Cancer Center, but Kupferman et al included only major glands and Galer et al included minor glands. 1.4 (1.3–1.4) 72.3 (70.7– 73.9) 8.0 (3.3–12.7)

Fifteen studies evaluated parotid surgery ( n = 517) with 45% ( n = 231) undergoing partial parotidectomy and 54% ( n = 279) total/radical parotidectomy. Thirteen of these also reported on neck dissections ( n = 363), where 32% of the children ( n = 117) underwent a neck dissection. There was no quantitative information regarding the diagnostic decision for total parotidectomy and neck dissec- tions. Eleven studies reported postoperative facial nerve function ( n = 430) and 17% of the children had the facial nerve sacrificed during surgery ( n = 75). Data regarding other surgical complications were insufficient for analysis. In two studies, all children with a

sacrificed facial nerve ( n = 7) underwent facial nerve reconstruction (Table 2). 11–14,16–18,20,21,23–28

3.3 Tumor characteristics

Fifteen studies had available data on histological distribution ( n = 426); MEC was most common with 53% ( n = 224), 55% ( n = 24), and 63% ( n = 60) in the parotid, submandibular, and minor salivary glands, respectively. The second most common type was AciCC in the parotid glands (30%; n = 125) and AdCC in the submandibular (14%; n = 6) and

203