xRead Articles - November 2022

Received: 23 September 2020 Revised: 21 January 2021 Accepted: 19 February 2021 DOI: 10.1002/hed.26667

O R I G I N A L A R T I C L E

Surgical treatment of the neck in patients with salivary gland carcinoma

Marie Westergaard-Nielsen MD 1 | Christian Godballe MD, PhD 1 | Jesper Grau Eriksen MD, PhD 2 | Stine Rosenkilde Larsen MD 3 | Katalin Kiss MD 4 | Tina Agander MD, PhD 4 | Benedicte Parm Ulhøi MD 5 | Birgitte Wittenborg Charabi MD 6 | Tejs Ehlers Klug MD, PhD, DMSc 7 | Henrik Jacobsen MD 8 | Jørgen Johansen MD, PhD 9 | Claus Andrup Kristensen MD, PhD 10 | Elo Andersen MD 11 | Maria Andersen MD 12 | Kristine Bjørndal MD, PhD 1 1 Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark 2 Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark 3 Department of Pathology, Odense University Hospital, Odense, Denmark 4 Department of Pathology, Rigshospitalet, Copenhagen, Denmark 5 Department of Pathology, Aarhus University Hospital, Aarhus, Denmark

6 Department of Otorhinolaryngology, Head and Neck Surgery, Rigshospitalet, Copenhagen, Denmark 7 Department of Otorhinolaryngology, Head and Neck Surgery, Aarhus University Hospital, Aarhus, Denmark 8 Department of Otorhinolaryngology, Head and Neck Surgery, Aalborg University Hospital, Aalborg, Denmark 9 Department of Oncology, Odense University Hospital, Odense, Denmark 10 Department of Oncology, Rigshospitalet, Copenhagen, Denmark 11 Department of Oncology, Herlev, Denmark 12 Department of Oncology, Aalborg University Hospital, Aalborg, Denmark

Correspondence Marie Westergaard-Nielsen, Department of Otorhinolaryngology – Head and Neck Surgery and Audiology, Odense University Hospital, J.B. Winsloews Vej 4, 5000 Odense C, Denmark. Email: marie.westergaard-nielsen@ rsyd.dk Funding information Dansk Kræftforsknings Fond; Kræftens Bekæmpelse; Region of Southern Denmark; Syddansk Universitet

Abstract Background: Elective neck dissection (END) in patients with salivary gland carcinoma is controversial and there are no universally accepted guidelines. Methods: Patients were identified from the Danish Head and Neck Cancer Group. Between 2006 and 2015, 259 patients with primary salivary gland carci noma were treated with END. Variables potentially associated with regional metastases were analyzed using logistic regression. Neck recurrence-free sur vival was calculated using the Kaplan – Meier method. Results: Occult metastases were found in 36 of the patients treated with END (14%) and were particularly frequent among patients with T3/T4 tumors and high-grade histology tumors. In multivariate analyses, high grade histology and vascular invasion were associated with occult metastases.

Associate Editor : James Rocco

Head & Neck. 2021;43:1898 – 1911.

1898

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