xRead Articles - November 2022

WESTERGAARD-NIELSEN ET AL .

1903

TABLE 2

Regression analysis of factors associated with cervical lymph node metastases

Univariate regression

Multivariate regression

Variables

pN+ n = 86 (%)

pN0 n = 254 (%)

OR

p value

OR

p value

Sex

Female

29 (33)

111 (44)

Male

57 (66)

143 (56)

2.5

<0.0001

2.4

0.016

Ratio (male: female)

2.0

0.8

Age

≤ 60 >60

29 (34)

117 (46)

57 (66)

137 (54)

1.7

0.047

ns

Median

64

61

24 – 88

6 – 94

Range

T-classification T1/T2

47 (55)

194 (76)

T3/T4

39 (45)

60 (23)

2.7

<0.001

ns

Tumor size <4 cm

60 (70)

210 (83)

≥ 4 cm

26 (30)

44 (17)

2.1

0.011

ns

Site

Minor gland

8 (9)

49 (19)

Major gland

78 (91)

205 (81)

2.3

0.036

ns

Parotid gland

57

154

Submandibular gland

17

45

Sublingual gland

4

6

Facial nerve impairment No

69 (80)

237 (93)

Yes

17 (20)

17 (7)

3.4

0.001

ns

Histological subtype Low-grade

35 (41)

190 (75)

High-grade

51 (59)

64 (25)

4.3

<0.001

3.0

<0.001

Surgical margins Close/free

40 (47)

162 (64)

Involved

46 (53)

92 (36)

2.0

0.005

ns

Perineural invasion No (218)

14 (16)

90 (35)

Yes (216)

46 (53)

82 (32)

3.6

<0.001

ns

Unknown (230)

26 (30)

82 (32)

Vascular invasion No (193)

17 (20)

87 (34)

Yes (55)

22 (26)

11 (4)

10.2

<0.001

7.0

<0.001

Unknown (416)

47 (55)

156 (61)

Abbreviation: OR, odds ratio.