xRead Articles - November 2022

Xiao et al

127

Table 6. Predictors of Nodal Metastasis.

Histology: Univariate

OR (95% CI)

P

Multivariate

OR (95% CI)

P

MEC

\ .001 \ .001

Age . 62 y

Age . 62 y

1.789 (1.584-2.022) 0.7 (0.578-0.847) 0.706 (0.516-0.965) 2.324 (2.05-2.635) 3.662 (2.887-4.644) 7.491 (5.722-9.807) 13.623 (10.455-17.75) 9.526 (8.216-11.044) 1.704 (1.368-2.123) 0.37 (0.15-0.911) 1.42 (1.146-1.758) 1.636 (1.141-2.346) 3.77 (2.452-5.797) 8.003 (5.152-12.434) 14.103 (9.957-19.975) 0.59 (0.363-0.959) 1.854 (1.588-2.165) 2.154 (1.609-2.883) 4.04 (2.924-5.582) 5.29 (3.904-7.167) 6.092 (4.947-7.501) 1.319 (1.016-1.712) 2.419 (1.256-4.656) 4.688 (2.42-9.082) 6.798 (3.706-12.47) 2.93 (1.896-4.527) 3.015 (1.472-6.176) 5.863 (2.832-12.141) 9.752 (4.772-19.93) 2.28 (1.012-5.139) 8.035 (3.295-19.595) 6.54 (3.457-12.371) 1.165 (1-1.358)

0.697 (0.555-0.874) 2.445 (1.846-3.238) 4.477 (3.247-6.173) 5.701 (4.104-7.919) 6.388 (5.01-8.147)

.002

\ .001 \ .001 \ .001 \ .001

African American

T2 T3 T4

Other

.029

\ .001 \ .001 \ .001 \ .001 \ .001

Male

T2 T3 T4

High grade

High grade

AC CA

\ .001

\ .001 \ .001

Age . 62 y

T4

4.53 (2.098-9.781)

Other

.031 .001 .007

High grade

10.621 (6.367-17.717)

Male

T2 T3 T4

\ .001 \ .001 \ .001

High grade

ANOS

Age . 62 y

.05

Male

1.329 (1.009-1.75) 1.836 (1.274-2.645) 2.991 (1.993-4.49) 3.35 (2.284-4.914) 5.145 (3.765-7.031)

.043 .001

Other

.033

T2 T3 T4

\ .001 \ .001 \ .001 \ .001 \ .001

\ .001 \ .001 \ .001

Male

T2 T3 T4

High grade

High grade

Ad Cy CA Male

.037 .008

T4

3.102 (1.342-7.169) 2.395 (1.292-4.439)

.008 .006

T2 T3 T4

High grade

\ .001 \ .001 \ .001

High grade

CA EPA T3

.003

T4

4.225 (1.531-11.655) 7.663 (2.84-20.672)

.005

\ .001 \ .001

\ .001

T4

High grade

High grade

SDC T3

\ .001 \ .001

.047

T4

9.857 (3.109-31.246) 4.993 (2.102-11.859)

\ .001 \ .001

T4

High grade

High grade

EMC

Age . 62 y

0.296 (0.125-0.699) 2.348 (1.018-5.417) 4.476 (1.334-15.02)

.005 .045 .015

Male

High grade

BCA T4

10.833 (2.288-51.299) 4.156 (1.361-12.693)

.003 .012

High grade

Abbreviations: AC CA, acinar cell carcinoma; Ad Cy CA, adenoid cystic carcinoma; ANOS, adenocarcinoma not otherwise specified; BCA, basal cell adeno carcinoma; CA EPA, carcinoma ex pleomorphic adenoma; CI, confidence interval; EMC, epithelial-myoepithelial carcinoma; MEC, mucoepidermoid carcinoma; OR, odds ratio; SDC, salivary ductal carcinoma.

mucoepidermoid carcinoma and adenocarcinoma NOS. High grade was most predictive of nodal disease for mucoepider moid carcinoma, acinar cell carcinoma, adenocarcinoma

NOS, adenoid cystic carcinoma, carcinoma ex pleomorphic adenoma, and salivary ductal carcinomas. In this study, higher T stage was independently a significant predictor of