xRead Articles - October 2022

6

Parkinson’s Disease

Mean Difference IV, Fixed, 95% CI

Weight (%)

LSVT

Control

Mean Difference IV, Fixed, 95% CI

Study or Subgroup 1.5.1 vowel L O Ramig1995 L O Ramig1996

Mean

SD

Total

Mean

SD

Total

81.2 82.47

4.65 3.62 3.92 3.9

26 22 21 14 83

68 67.83

4.31 4.94 4.79 4.4

19 13 12 15 59

8.3 6.1 5.7 6.3 26.5

13.20 [10.56, 15.84] 14.64 [11.56, 17.72] 13.70 [10.51, 16.89] 11.90 [8.88, 14.92] 13.33 [11.85, 14.81]

L O Ramig 2001a L O raming 2001b Subtotal (95% CI) Heterogeneity: Chi 2 = 1.62, df = 3 ( P = 0.66); I 2 = 0% Test for overall effect: Z = 17.66 ( P < 0.00001) 82.4 82.4

68.7 70.5

1.5.2 Rainbow passage L O Ramig1995 L O Ramig1996

74.33 75.19

4.38 4.37 4.22 4.2

26 22 21 14 83

68.2 67.89 68 71.9

3.33 3.37 3.36 4.1

19 13 11 15 58

11.4 8.7 8.0 6.3 34.5

6.13 [3.88, 8.38] 7.30 [4.71, 9.89] 7.30 [4.62, 9.98] 6.00 [2.98, 9.02] 6.67 [5.38, 7.97]

L O Ramig 2001a L O raming 2001b Subtotal (95% CI) Heterogeneity: Chi 2 = 0.85, df = 3 ( P = 0.84); I 2 = 0% Test for overall effect: Z = 10.09 ( P < 0.00001) 1.5.3 Monologues L O Ramig1995 L O Ramig1996 L O Ramig 2001a L O raming 2001b Subtotal (95% CI) Heterogeneity: Chi 2 = 1.51, df = 3 ( P = 0.68); I 2 = 0% Test for overall effect: Z = 6.32 ( P < 0.00001) 75.3 77.9 69.17 69.94 69.4 74.5 4.1 3.55 3.39 4 16 22 12 14 64

66.24 65.68

2.11 2.49 2.72 3.9

13 13 6 15 47

10.8 14.4 6.9 7.0 39.1

2.93 [0.62, 5.24] 4.26 [2.25, 6.27] 3.60 [0.70, 6.50] 5.10 [2.22, 7.98] 3.93 [2.71, 5.14]

65.8 69.4

Total (95% CI) Heterogeneity: Chi 2 = 98.15, df = 11 ( P < 0.00001); I 2 = 89% Test for overall effect: Z = 18.96 ( P < 0.00001) Test for subgroup differences: Chi 2 = 94.18, df = 2 ( P < 0.00001), I 2 = 97.9% 230 164

100.0

7.36 [6.60, 8.12]

-10 -5

0

5 10

Control

LSVT

Figure 4: SPL immediately after the treatment during a reading of vowel, rainbow passage, and monologues.

Mean Difference IV, Random, 95% CI

Mean Difference IV, Random, 95% CI

LSVT

Control

Weight (%)

Total

SD

Total

Mean

SD

Study or Subgroup 1.4.1 vowel Geralyn Schulz 2021 L O Ramig1996

Mean

18 13 15 22 68

12.3 9.7 11.4 6.7 40.1

7.50 [5.11, 9.89] 9.38 [5.61, 13.15] 9.20 [6.36, 12.04] 3.70 [-1.93, 9.33] 8.03 [6.25, 9.82]

3.66 6.04

20 22 14 22 78

71.9 68.2 70.6 76.1

3.85 4.41 3.7 10.6

79.4 77.58

L O raming 2001b L O Raming 2018 Subtotal (95% CI) Heterogeneity: Tau 2 = 0.58; Chi 2 = 3.61, df = 3 ( P = 0.31); I 2 = 17% Test for overall effect: Z = 8.81 ( P < 0.00001) 79.8 79.8 4.1 8.3

1.4.2 Rainbow Passage L O Ramig1996

3.05 [0.44, 5.66] 4.20 [1.53, 6.87] 5.50 [2.22, 8.78] 4.07 [2.45, 5.69]

13 15 22 50

11.9 11.8 10.6 34.2

3.97 4.1 4.8

22 14 22 58

67.25 71.9 71.3

3.5 3.2 6.2

70.3 76.1 76.8

L O raming 2001b L O Raming 2018 Subtotal (95% CI) Heterogeneity: Tau 2 = 0.00; Chi 2 = 1.33, df = 2 ( P = 0.51); I 2 = 0% Test for overall effect: Z = 4.93 ( P < 0.00001) 1.4.3 Monologues L O Ramig1996 L O raming 2001b Subtotal (95% CI) Heterogeneity: Tau 2 = 0.00; Chi 2 = 0.91, df = 1 ( P = 0.34); I 2 = 0% Test for overall effect: Z = 3.10 ( P = 0.002) Total (95% CI) Heterogeneity: Tau 2 = 6.64; Chi 2 = 36.16, df = 8 ( P < 0.0001); I 2 = 78% Test for overall effect: Z = 5.19 ( P < 0.00001) Test for subgroup differences: Chi 2 = 25.65, df = 2 ( P < 0.00001), I 2 = 92.2% 66.07 72.7 2.52 3.6 22 14 36 172 64.33 69.5 2.4 3.2 13 15 28 146

1.74 [0.06, 3.42] 3.20 [0.71, 5.69] 2.20 [0.81, 3.59]

13.6 12.1 25.7

100.0

5.19 [3.23, 7.15]

-10

-5

0

5

10

Control

LSVT

(a) Figure 5: Continued.