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augmentation with methylcellulose or hyaluronic acid None 1 injection CSI Number of patients reporting improvement of symptoms None 1 or more injections

physiotherapy program None Up to 3 sessions LCQ Subjective reporting of cough frequency and sleep disturbance Prospective case series 33; 33 (11/22) 62.6 SPEICH-C None 5 sessions Vocal loading test completion,

Symptom frequency and severity rating scale LCQ CAPE-V

Cough frequency in 1-hour LCQ

One-on-one standardized healthy lifestyle advice 45-min sessions (41) 4 sessions LCQ 24-hr cough frequency (coughs/hr) Cough severity VAS VPQ 2 or more sessions

CSI Number of injections

Number of injections

Retrospective case series 27; 27 (6/21) 62.4 Breath training therapy 45-min sessions None 2 – 4 sessions CSI Maximum phonation time None 1 or more Subjective cough

Secondary outcome measure(s)

Aerodynamic measures

Urge-to-cough VAS

Urge-to-cough VAS

severity

accuracy, effect on cough, effect on

acoustic measures

7 – 10 days Citric acid cough challenge

Accuracy of therapy technique rated by SLP

challenge

Primary outcome measure

injections

Treatment

duration

Prospective case series 17; 17 (8/9) 61 Speech pathology program for chronic cough 30-min sessions None Up to 4 sessions Capsaicin cough series 23; 23 (10/13) 60 Cough suppression

Standard speech pathology treatment 30 – 45-min sessions (9)

NC : no intervention (11)

PC : voluntary suppression (9)

Comparator

intervention (n patients)

+ corticosteroid injection : 1% lidocaine with

TABLE I.

Continued

30 – 45-min sessions (9)

epinephrine (1:100,000) or 0.5% bupivacaine

+ triamcinolone acetonide 200 mg/5 mL or methylprednisolone 80 mg/1 mL

botulinum toxin A injection

Mindfulness based-stress reduction 30 min daily (10)

Physiotherapy, speech and language therapy intervention (PSALTI)

treatment and supplemental prerecorded videos for home practice

23; 23 (12/11) 67.7 Vocal fold injection

Simpson et al (2018) Dallas, TX, USA Retrospective case series 18; 18 (3/15) 60 Local anesthetic

23; 21 (2/19) 61 EMG-guided laryngeal

Experimental intervention (n patients)

45-min sessions (34)

Standard speech pathology

Chamberlain et al (2017) London, England, UK Parallel RCT 75; 63 (24/51) E: 61 C: 56 Kapela et al (2019) Newcastle, NSW, Australia Parallel RCT 18; 15 (2/16) E: 59 C: 57

Young et al (2009) Manchester, England, UK Parallel RCT 30; 30 (10/20) E: 60.2 NC: 54.2 PC: 61.1

Average

age in

years

# Patients enrolled;

completed therapy (males/females)

case series

case series

Study

design

Australia

Yang et al (2019) Loma Linda, CA, USA

Ryan et al (2010) Newcastle, NSW, Australia

Litts et al (2018) Aurora, CO, USA Retrospective

Patel et al (2011) London, England, UK Prospective case

trial number (year) Location

Procedural therapy Sasiesta et al (2016) Rochester, MN, USA Retrospective

Vertigan et al (2017) Newcastle, NSW,

Author or clinical

Laryngoscope 132: January 2022

Wamkpah et al.: Multimodal Treatments for Neurogenic Cough

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