xRead - Globus and Chronic Cough (April 2024)

Wamkpah et al.

Page 26

Author Manuscript Author Manuscript Author Manuscript Author Manuscript # Patients enrolled; completed therapy (males/ females) Average age in years Comparator Treatment duration Primary outcome measure

Secondary outcome measure(s)

Urge-to-cough VAS

4 sessions LCQ 24-hr cough frequency (coughs/hr) 2 or more

Cough severity VAS VPQ

Symptom frequency

and severity rating scale LCQ CAPE-V

Urge-to-cough VAS

Cough frequency in 1 hour LCQ

LCQ Subjective reporting of cough frequency and sleep disturbance

CSI Maximum phonation time

Aerodynamic measures

Number of injections

None 1 injection CSI Number of patients

reporting improvement of symptoms

CSI Number of injections

7–10 days Citric acid cough

challenge

Accuracy of therapy

technique rated by SLP

Capsaicin cough

challenge

62.6 SPEICH-C None 5 sessions Vocal loading test

completion, accuracy,

effect on

cough, effect on acoustic measures

Subjective

cough severity

sessions

None Up to 4

sessions

None Up to 3

sessions

None 2–4

sessions

None 1 or more

injections

None 1 or more

injections

NC: no intervention (11) PC: voluntary

intervention (n patients)

suppression (9) One-on-one

standardized healthy lifestyle advice

45-min sessions (41) Standard speech

pathology treatment

30–45-min sessions (9)

60 Local anesthetic +

corticosteroid injection: 1% lidocaine with

Experimental

intervention (n patients)

Mindfulness based-stress reduction 30 min daily (10)

Physiotherapy, speech and language therapy

intervention (PSALTI) 45-min sessions (34) Standard speech

pathology treatment and supplemental prerecorded videos for home practice 30–45-min sessions (9)

17; 17 (8/9) 61 Speech pathology program for chronic cough 30-min sessions 23; 23 (10/13) 60 Cough suppression 33; 33

physiotherapy program

62.4 Breath training therapy 45-min sessions

61 EMG-guided laryngeal botulinum toxin A injection

67.7 Vocal fold injection augmentation with

methylcellulose or hyaluronic acid

E: 60.2

NC: 54.2

PC: 61.1

E: 61

C: 56

E: 59

C: 57

(10/20)

(24/51)

(2/16)

(11/22)

27; 27

(6/21)

23; 21

(2/19)

23; 23

(12/11)

18; 18

(3/15)

number (year) Location Study design Young et al (2009) Manchester,

Parallel RCT 30; 30

Parallel RCT 75; 63

Parallel RCT 18; 15 Prospective case series

Prospective

case series

Prospective

case series

Retrospective case series

Retrospective case series

Retrospective case series

Retrospective case series

England, UK

London,

England, UK

Newcastle, NSW,

Australia

Newcastle, NSW,

Australia

London,

England, UK

Newcastle, NSW,

Australia

Loma Linda, CA, USA

Rochester,

MN, USA

Aurora, CO, USA

Dallas, TX, USA

Chamberlain et al (2017)

Kapela et al (2019)

Ryan et al (2010)

Patel et al (2011)

Vertigan et al (2017)

Yang et al (2019)

Sasiesta et al (2016)

Litts et al (2018)

Simpson et al (2018)

Author or

clinical trial

Procedural therapy

Laryngoscope . Author manuscript; available in PMC 2022 January 01.