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only acute rhinosinusitis but also adenoiditis, as confirmed by endoscopy. Int J Pediatr Otorhinolaryngol . 2007;71(4):581-583. 2301. Li C, Peng Hwa T, Schussler E, Pearlman AN. Immunologic evaluation of pediatric chronic and recurrent acute rhinosi nusitis. Am J Rhinol Allergy . 2020;34(1):93-99. 2302. Shaikh N, Hoberman A, Kearney DH, et al. Signs and symp toms that differentiate acute sinusitis from viral upper respira tory tract infection. Pediatr Infect Dis J . 2013;32(10):1061-1065. 2303. Lin SW, Wang YH, Lee MY, et al. Clinical spectrum of acute rhinosinusitis among atopic and nonatopic children in Tai wan. Int J Pediatr Otorhinolaryngol . 2012;76(1):70-75. 2304. McQuillan L, Crane LA, Kempe A. Diagnosis and man agement of acute sinusitis by pediatricians. Pediatrics . 2009;123(2):e193-198. 2305. Newton L, Kotowski A, Grinker M, Chun R. Diagnosis and management of pediatric sinusitis: a survey of primary care, otolaryngology and urgent care providers. Int J Pediatr Otorhi nolaryngol . 2018;108:163-167. 2306. Shaikh N, Wald ER, Jeong JH, et al. Development and modifi cation of an outcome measure to follow symptoms of children with sinusitis. JPediatr . 2019;207:103-108.e101. 2307. Huang SW, Small PA, Jr. Rapid diagnosis of bacterial sinusi tis in patients using a simple test of nasal secretions. Allergy Asthma Proc . 2008;29(6):640-643. 2308. Clement PA, Bluestone CD, Gordts F, et al. Management of rhinosinusitis in children. Int J Pediatr Otorhinolaryngol . 1999;49(Suppl 1):S95-S100. 2309. Wen YS, Lin CY, Yang KD, Hung CH, Chang YJ, Tsai YG. Nasal nitric oxide is a useful biomarker for acute uni lateral maxillary sinusitis in pediatric allergic rhinitis: a prospective observational cohort study. World Allergy Organ J . 2019;12(4):100027. 2310. Cronin MJ, Khan S, Saeed S. The role of antibiotics in the treat ment of acute rhinosinusitis in children: a systematic review. Arch Dis Child . 2013;98(4):299-303. 2311. Gallant JN, Basem JI, Turner JH, Shannon CN, Virgin FW. Nasal saline irrigation in pediatric rhinosinusitis: a systematic review. Int J Pediatr Otorhinolaryngol . 2018;108:155-162. 2312. Ragab A, Farahat T, Al-Hendawy G, Samaka R, Ragab S, El Ghobashy A. Nasal saline irrigation with or without systemic antibiotics in treatment of children with acute rhinosinusitis. Int J Pediatr Otorhinolaryngol . 2015;79(12):2178-2186. 2313. Wong SJ, Levi J. Management of pediatric orbital cellulitis: a systematic review. Int J Pediatr Otorhinolaryngol . 2018;110:123 129. 2314. Rahbar R, Shapshay SM, Healy GB. Mitomycin: effects on laryngeal and tracheal stenosis, benefits, and complications. Ann Otol Rhinol Laryngol . 2001;110:1-6. 2315. Todman MS, Enzer YR. Medical management versus surgical intervention of pediatric orbital cellulitis: the importance of subperiosteal abscess volume as a new criterion. Ophthal Plast Reconstr Surg . 2011;27(4):255-259. 2316. Peña MT, Preciado D, Orestes M, Choi S. Orbital complica tions of acute sinusitis: changes in the post-pneumococcal vac cine era. JAMA Otolaryngol Head Neck Surg . 2013;139(3):223 227. 2317. McKinley SH, Yen MT, Miller AM, Yen KG. Microbiology of pediatric orbital cellulitis. Am J Ophthalmol . 2007;144(4):497 501.