xRead - Nasal Obstruction (September 2024) Full Articles

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201

ICAR SINONASAL TUMORS

TABLE XXI.B.3 (Continued)

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusion

Cheung et al. 655

1. Five of seven were p53 positive, the other two of seven were p16 positive 2. Four of seven were positive for HPVonPCR 3. Severe dysplasia and p53 associated with malignant progression 1. Progressive upregulation of 11 genes ( CALD1 , COL1A1 , COL3A1 , COL4A2 , COL5A2 , FN1 , ITGA5 , LGALS1 , MMP11 , SERPINH1 , SPARC ) that correlated with severity of disease 2. Gene set enrichment analysis identified epithelial mesenchymal transition, extracellular matrix organization, and coagulation to be significant 3. Progressive upregulated genes can improve concordance of histologic classification of IP, which may impact prognostication and treatment strategies 1. EGFR mutation in 21 out of 29 and KRAS in five out of 29 2. Mutually exclusive TP53 or CDKN2A mutation in 28 out of 29 TERT copy number gains in eight of 29but no TERT promoter mutation 1. IP-SCC and SCC ex-oncocytic papillomas have a distinct molecular phenotype compared to other aerodigestive tract SCC 1. EGFR mutation in 25 out of 28 IPs, six out of 10 IP-SCCs 2. Deficiency in mismatch repair protein (dMMR)/microsatellite instability (MSI-H) in four out of 125SNSCCs 3. IP displayed intact MMR phenotype 4. Molecular classification of sinonasal tumors can provide useful information for individualized therapeutic strategy (Continues)

1. p53

2010 3

Retrospective cohort

Five IP-SCCs, one IP with CIS, one SCC with exophytic papilloma

mutational status 2. HPV status 3. Prognosis

Tonget al. 1140

2022 4

Retrospective case series

Six IPs, five IPs with CIS, 13 IP-SCCs

Upregulation of genes in IP with CIS and IP-SCC

Brown et al. 660

1. Presence of mutations ( EGFR , KRAS , TP53 , CKN2A , TERT ) 2. Copy number gains of mutations

2021

4

Retrospective case series

29 SCCs (IP-SCC or ex-oncocytic papilloma)

Hieggelke et al. 1138

2021

4

Retrospective case series

28 IPs, 10 IP-SCCs, 43 SNSCCs (keratinizing), six SNUCs, seven ITACs, 11 ACCs, two SNECs, six exophytic papillomas, one oncocytic papilloma, 10 SNSCC cell lines

Molecular

classification of IPand IP-SCC