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209

ICAR SINONASAL TUMORS

TABLE XXII.B.1 Evidence surrounding relevant immunohistochemistry markers for non-ITAC. Study Year LOE Study design Study groups Biomarkers

Conclusion

Yue et al. 1174

CK7 + , CDX2–, P63-, calponin–, S100 focal expression, SOX10 +

2021

4

Retrospective case series

17 non-ITACs

CK7, CDX2, P63, calponin, S100, SOX10 SOX10, MUC1, S100, MUC5ac, SATB2, CK20, CDX2, MUC2, MUC6, p63 CK7,MUC4,

Baneckova et al. 1184

2020 4

Retrospective case series

Nine low-grade non-ITACs

Low-grade non-ITAC are (1) CK7, MUC4, SOX10, MUC1, S100, MUC5ac, and SATB2 positive; (2) CK20, CDX2, MUC2, and MUC6 p63 all negative

Taverna et al. 1186 2019 4

MUC1, 2, 4, 5AC, 6

MUC1 more expressed ITACs than non-ITACs MUC2 only in ITACs. MUC4 and MUC5AC were similarly expressed

Retrospective case series

51 ITACs: four

non-ITACs, and 11 salivary gland-type carcinomas

Pirrone et al. 1189

2017 4

Retrospective case series Retrospective case series

Five non-ITACs

OTX1,OTX2

OTX1 only in non-ITAC

Negative CK20 and CDX2, and positive for CK7, but SSH and some non-ITAC have focal, S100, DOG1, and SOX10 CDX-2 and CK20 negative in non-ITAC CK7 + , CK20–, MUC2-, CDX2–

CK20, CDX2, CK7, S100,

Purgina

2014 4

23 non-ITACs, 17 ITACs, and five SSHs

et al. 1180

DOG1, SOX10

Tilson et al. 1187

2013 4

Retrospective case series Retrospective case series

Six non-ITACs

CDX-2, CK20

Joet al. 1173

2009 4

29 low-grade non ITACs

CK7, CK20,

S100, MUC2, CDX2

Resto et al. 1185

2006 4

Retrospective case series

Four cases of non-ITACs

CK7, CK20,

ITAC: CK7 + , CK20 + ,MUC2 + phenotype non-ITAC: CK7 + , CK20–, MUC2– phenotype

Muc2,MUC5

Franchi et al. et al. 1156

CDX2, CK7, CK20

CDX2–, CK7 + , CK20–

2014 4

Retrospective case series

Four cases of

tubulopapillary low-grade non-ITACs

Choi 1183

2003 4

Retrospective case series

Five cases of non-ITACs

CK7, CK20,

Non-ITAC tumors exclusively CK7 +

CK14, CK19, AE1–3, CAM5.2

Skalova et al. 1181

CK14 and CK19 restricted expression, AE1–3, CAM5.2 strong expression, S100 positive

2018 4

Retrospective case series

Six low-grade

CK14, CK19, CEA, S100, CD10, GFAP, p63, CD57, HER2/neu oncoprotein, GFAP, alfa SMA AE1–3, CAM5.2

tubulopapillary ACs

Abbreviation: ITAC, intestinal-type adenocarcinoma.