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ICAR SINONASAL TUMORS

TABLE XXII.B.2 Evidence on treatment modalities for non-ITAC.

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusions

Surgery Meccariello et al. 259

2015 2

Systematic

1826 patients

Evaluation of safetyand

ERis a safe and effective treatment modality for adenocarcinomas

reviewand meta analysis

encompassing 39 articles; 1005 with histology information

effectiveness of endoscopic management of sinonasal ade nocarcinomas 1. LRC 2. OS 3. Disease-free rates 1. Postoperative mortality 2. Postoperative complica tions 3. DSS 4. OS 5. RFS

865 ITAC (140 non-ITACs) 48 patients with

Vergez et al. 261

Reduced duration of hospitalization for ER group, oncological outcomes, and early morbidity comparable between two groups

2012 3

Retrospective cohort

adenocarcinomas, 24 underwent CFR and 24 underwent ER 334 patients, 107 with adenocarcinoma

Ganly et al. 174

2005 3

Retrospective cohort

Overall mortality of 4.5% and complication rate of 33% for CFR

Kiliç et al. 53

DSS

1. Highest DSS was in surgery-only patients 2. Treatment modalities that included surgery had higher survival rates than those that did not ER could be used as a single treatment modality for primary early-stage low-grade sinonasal adenocarcinoma

746 patients, 464 of whomwith

2018 4

Retrospective database review (SEER)

non-ITAC between 1973 and 2013

Turri-Zanoni et al. 1150

2015 4

Retrospective

61 adenocarcinoma T1–2 patients, 57 ITAC—four non-ITAC, 33 surgery alone—28 surgery + RT

1. OS 2. RFS

case–control study

Bhayani

OS

ER not associated with adverse outcomes

2014 4

Retrospective case series

66 patients, 31 of whomhad non-ITAC 12 patients with

et al. 1158

Nicolai et al. 1194

2007 4

Retrospective case series

1. DSS 2. DFS

ER for T1–2 lesions offers an alternative to external procedures

adenocarcinoma underwent ER

Radiotherapy Chenet al. 1178

2015 3

Retrospective cohort

325 patients, 300 of whomhad non-ITAC

DSS

Compared with RT alone, surgery and surgery with adjuvant RT were associated with improved DSS ER followed by RT gives comparable oncological results to those of standard external approaches (Continues)

Bogaerts

1. OS 2. DSS 3. Local control rate

2008 3

Retrospective cohort

44 patients with

et al. 1193

adenocarcinoma treated with surgery + RT