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ICAR SINONASAL TUMORS

TABLE XXII.B.3 Evidence on survival in non-ITAC patients.

Clinical endpoint

Study

Year LOE Study design Study groups

Conclusion

Non-ITAC histology associated with less favorable prognosis

Evaluation of safetyand

1826 patients; 1005 with histology information 865 ITAC (140 non-ITAC)

Meccariello et al. 259

2015 2

Systematic

reviewand meta analysis

effectiveness of endoscopic management of sinonasal ade nocarcinomas Evaluation of outcomes for patients with AC

König et al. 1197

2019 3

Population based

20 patients with AC,

2-year cumulative survival 100%, 5-year 83%, and 10-year 83% for non-ITAC group

seven of whom with non-ITAC (four low-grade, three high-grade), follow-up 100%, median follow-up time 89 months for entire cohort

consecutive prospective cohort

Chenet al. 1178

DSS

1. 5-year DSS rate of 71.2% for non-ITAC patients 2. No significant difference in terms of survival between ITAC and non-ITAC subtypes 3. Surgery alone or adjuvant RT, associated with more favorable prognosis No significant difference in terms of survival between low- and high-grade tumors

2015 3

Retrospective cohort

325 patients, 300 of whomhad non-ITAC

Choussy

2008 3

Multicenter

418 patients with ethmoid

Determination of risk factors and evaluation of treatment

et al. 1196

retrospective cohort

adenocarcinoma, divided into two groups: ITAC and poorly differentiated carcinoma ( n = 248) versus well-differentiated carcinoma ( n = 107)

Yue et al. 1174

14 out of 17 patients had no recurrence for a median of 60 months after diagnosis

2021

4

Retrospective case series

Study group: 17 patients with

Clinicopathological and immuno histochemical features of the tumors

low-grade non-ITAC

Control group: 10

patients with CRS involving the turbinates

Bignami et al. 363 2018 4

Retrospective case series

22 patients with non-ITAC

Outcomes and prognostic factors of sinonasal nonsalivary non-ITAC

1. Non-ITAC 5-year OS of 95.2% ± 4.7% 2. High grade, high pT4 stage, and positive surgical margins are independent negative prognostic factors 1. 5-year DSS 63.7%, 10-year DSS 57.9%, and 20-year DSS 48.3% for non-ITAC combined group 2. Improved survival for ITAC compared to adenocarcinoma not otherwise specified, specifically (Continues)

Kiliç et al. 53

DSS

746 patients, 464 of whomwith

2018 4

Retrospective database review (SEER)

non-ITAC between 1973 and 2013