xRead - Nasal Obstruction (September 2024) Full Articles

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231

ICAR SINONASAL TUMORS

TABLE XXIII.B.1 Evidence surrounding sinonasal chondrosarcoma.

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusion

Sinonasal ChS a : 100/736

Rimmer

2021

4

Retrospective database study (NCDB)

OS

1. Sinonasal ChS is primarily treated with surgery and adjuvant RT 2. PBRT confers higher survival than conventional RT 3. 1-, 2-, 5-, and 10-year OS: 97.0%, 90.6%, 80.5%, and 74.9%, respectively 1. CSS is not decreased in patients receiving surgery alone 2. A surgery only strategy could be considered leaving PBRT for cases of relapse 3. 5- and 10-year CSS: 95.2% 1. Endoscopic transnasal surgery is a good option to achieve maximal safe resection 2. 3-year CSS and RFS: 91.1% and 83.7% 3. 5-year CSS and RFS: 90.5% and 80.8% 1. Early diagnosis and adequate surgical resection are essential to ensure satisfactory outcomes 2. Local progression is the main cause of death 3. 5-year CSS: 83.3% 1. Early diagnosis and adequate surgical resection are essential to ensure satisfactory outcomes 2. 5-year OS: 56.4% 1. Sinonasal MeC is an aggressive subtype of ChS, with predilection for young women 2. MeC mandates for aggressive surgery and adjuvant therapy 3. 1-year OS and CSS: 81.8% b 4. 3-, 5-, and 10-year OS and CSS: 63.6% b

et al. 1259

Simon et al. 1258

Sinonasal ChS a : 13/47 §

2018 4

Retrospective case series

CSS

Sinonasal ChS a : 14/35 c,§

Vaz-Guimaraes et al. 1257

2017 4

Retrospective case series

1. CSS 2. RFS

Guoet al. 266

Sinonasal ChS a : 24/24 CSS

2013 4

Retrospective case series

Prado et al. 1256

Sinonasal ChS a : 11/16 OS

2009 4

Retrospective case series

Knott et al. 1255

Sinonasal ChS a : 13/13 1. OS 2. CSS

2003 4

Retrospective case series

Gadwal et al. 1254 2000 4 1. Pediatric craniofacial ChS is more frequently low-grade and associated with favorable prognosis 2. 1-, 3-, 5-, and 10-year OS and CSS: 100.0% b Abbreviations: ChS, chondrosarcoma; CSS, chondrosarcoma-specific survival; FS, frozen section; MeC, mesenchymal chondrosarcoma; OS, overall survival; PBRT, proton beam radiotherapy; RFS, recurrence-free survival; RT, radiation therapy. a Reported as the ratio between patients affected by a sinonasal chondrosarcoma as per the definition reported in Material and Methods and total number of patients. b Calculated. c Estimated based on breakdown by extension. § Subsequent row values refer to the entire series and single-patient data could not be extracted. Retrospective case series Pediatric sinonasal ChS a : 8/14 1. OS 2. CSS