xRead - Nasal Obstruction (September 2024) Full Articles

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241

ICAR SINONASAL TUMORS

TABLE XXIV.A.2 Evidence surrounding staging systems for ONB.

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusions

33 studies; N = 128

DFS

Kadish stage C/D and Hyams grading III/IV significantly affected DFS 1. Increasing age, treatment with chemotherapy, and positive or unreported margin status portended worse DFS ( p < 0.05) 2. Both Kadish and Dulguerov staging systems were prognostic for worse DFS and OS ( p < 0.05), with Kadish C representing a heterogeneous group 5-year survival 44%–91% At presentation, 90% are Kadish B/C underwent RT versus non-RT were 85.3% versus 70.4% and 10-year OS were 68.2% versus 56.8% in stage C patients 2. In Kadish A/B, RT was not an independent prognostic factor for OS of modified Kadish stage A and B patients 1. 5- and 10-year DFS was 67.6% (95% CI: 60.7%–73.6%) and 51.9% (95% CI: 43.8%–59.4%), respectively 2. Dural infiltration at presentation was a significant predictor of OS 1. 5-year OS of patients who Predictors of cause-specific mortality for ONB included age, tumor stage, surgery, and chemotherapy 1. 5-year OS for patients with Kadish stages A, B, and C was 100%, 83.6%, and 64.2%, respectively 2. 5-year OS for Morita stages A, B, C, and D was 100%, 83.6%, 70.7%, and 50.0%, respectively Model of multiple tumor history, orbital invasion, carotid canal invasion, modified Kadish stage, delivery sequence of RT and surgery, and sequence of chemotherapy and surgery predicted outcome better than conventional staging systems and DFS in primary cases ( n = 278,HR = 2.22, 95% CI: 1.37–3.59)

Meerwein et al. 1376

2021

2

Systematic

patients with ONB

reviewand meta analysis reviewand meta analysis

Arnold et al. 1379

2020 2

Systematic

21 studies; N = 399

OS

patients with ONB

Safi et al. 1350

N = 94 patients with pediatric ONB

OS

2020 2

Systematic

reviewand meta analysis

Duoet al. 1364

2022 4

Retrospective database study (SEER)

N = 513 patients with ONB

OS

Lechner et al. 15

2022 4

Retrospective case series

N = 404 patients with ONB

OS

Liuet al. 1380

2021

4

Retrospective database study (SEER) Retrospective case series

N = 826 patients with ONB

OS

Sunet al. 1381

2021

4

N = 142 patients with ONB

OS

Yanget al. 1382

2020 4

Retrospective case series

N = 154 patients with ONB

OS

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