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KUANetal.

TABLE XXIV.A.6 Evidence surrounding the role of radiation therapy for ONB.

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusions

Vuong et al. 1377

33 studies; N = 492

OS

RT offered survival advantage in Hyams grades III/IV

2021

2

Systematic

patients with ONB

reviewand meta analysis reviewand meta analysis

Marinelli et al. 1386

2018 2

Systematic

48 studies; N = 118 ONB presenting with distant disease

OS

Multimodality therapy offered benefit over single or no therapy

Duoet al. 1364

N = 513 patients with ONB

OS

5-year OS rates of patients who underwent RT versus non-RT were 85.3% versus 70.4% Delays during, and prolongation of RT, for ONB appears to be associated with decreased OS Surgery and adjuvant RT is associated with improved patient survival Patients who received surgery combined with CRT showed better OS (89.4% vs. 53.6%, p = 0.001) and PFS (87.8% vs. 53.6%, p = 0.001) compared with those who did not undergo surgery Surgery and RT had best survival Multivariate analysis demonstrated lymph node status, orbital invasion, and the combination of surgery and RT to be independent prognostic factors Model of multiple tumor history, orbital invasion, carotid canal invasion, modified Kadish stage, delivery sequence of RT and surgery, and sequence of chemotherapy and surgery predicted outcome better than conventional staging systems Patients with adjuvant RT had a 5-year PFS of 46.7%, whereas those treated with surgery alone had a 5-year PFS of 19.4% ( p = 0.01) (Continues) Similar OS, PFS, LRC, and DMFS between groups

2022 4

Retrospective database study (SEER) Retrospective database study (NCDB) Retrospective database study (SEER) Retrospective case series

Tsutsumi et al. 1369

2022 4

N = 814 patients with ONB

OS

Vuong et al. 1387

N = 733 patients with ONB

OS

2022 4

Wanget al. 1388

2021

4

N = 37 ONB with frontal lobe involvement

1. OS 2. PFS

Zenget al. 484

2021

4

Retrospective case series Retrospective case series

N = 64 patients with ONB N = 37 patients with ONB

OS

Liuet al. 488

2020 4

1. OS 2. PFS 3. LRC 4. DMFS

Songet al. 1385

2020 4

Retrospective case series

N = 217 patients with ONB

OS

Yanget al. 1382

2020 4

Retrospective case series

N = 154 patients with ONB

OS

Kimet al. 253

2019 4

Retrospective case series

N = 28 patients with ONB

OS