xRead - Nasal Obstruction (September 2024) Full Articles

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KUANetal.

TABLE XXIV.A.7 Evidence surrounding the role of systemic therapy in ONB.

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusions

Vuong et al. 1377

33 studies; N = 492

OS

Chemotherapy did not offer survival benefit to any Hyams subgroup Increasing age, treatment with chemotherapy, and positive or unreported margin status portended worse DFS ( p < 0.05) Multimodality therapy offered benefit over single or no therapy

2021

2

Systematic

patients with ONB

reviewand meta analysis

Arnold et al. 1379

2020 2

Systematic review

21 studies; N = 399

1. OS 2. DFS

patients with ONB

OS

Marinelli et al. 1386

48 studies; N = 118 ONB presenting with distant disease

2018 2

Systematic

reviewand meta analysis

Vuong et al. 1387

2022 4

Retrospective database study (SEER) Retrospective database study (SEER) Retrospective database study (SEER) Retrospective case series

N = 733 patients with ONB

OS

The use of chemotherapy did not confer survival advantage

Brisson et al. 1372

N = 636 patients with ONB

OS

The only patient population that derived benefit from CT were patients who did not receive surgery and were treated with CT and/or RT (HR 0.3, 95% CI: 0.14–0.61, p < 0.001) Predictors of cause-specific mortality for ONB included age, tumor stage, surgery, and chemotherapy Patients who received surgery combined with RT/CRT showed better OS and PFS compared with those who did not undergo surgery analyses, chemotherapy was associated with inferior DSS 2. Among the subset with local or regional disease treated with surgery and/or RT, chemotherapy remained associated with inferior DSS 3. This analysis does not support chemotherapy to improve either DSS or OS in primary ONB/ON treatment, after controlling for known ONB prognostic factors available from SEER Model of multiple tumor history, orbital invasion, carotid canal invasion, modified Kadish stage, delivery sequence of RT and 1. In adjusted multivariable surgery, and sequence of chemotherapy and surgery predicted outcome better than conventional staging systems

2021

4

Liuet al. 1380

2021

4

N = 826 patients with ONB

OS

Wanget al. 1388

1. OS 2. PFS

2021

4

N = 37 ONB with frontal lobe involvement

Crammer et al. 1371

2020 4

Retrospective database study (SEER)

N = 797 patients with ONB

1. OS 2. DSS

Yanget al. 1382

2020 4

Retrospective case series

N = 154 patients with ONB

OS

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