xRead - Nasal Obstruction (September 2024) Full Articles

20426984, 0, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.23262, Wiley Online Library on [02/01/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

264

KUANetal.

TABLE XXIV.D.1 Evidence surrounding surgical resection of sinonasal mucosal melanoma.

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusion

Hur et al. 279

1. OS 2. DFS

1. OS improved in endoscopic compared to open resection 2. No difference in DFS between endoscopic and open resection 1. Higher Ki67 and mitotic rates were associated with worsened OSandRMFS 2. Brisk tumor-infiltrating lymphocytes (TILs) were associated with improved RMFS 3. Patients on immunotherapy withKi67 < 40% had better 3-year OS than those with higher Ki67 index 1. 2-year OS 72% for negative margins, 36% for positive margins, 16% for no surgery 2. OS following surgery with 1. OS24% 2. Increased age and distant metastasis associated with decreased survival 3. T4 disease associated with worse survival 4. Negative surgical margins associated with improved survival 5. Immunotherapy associated with improved survival in metastatic disease 1. Regional nodal and distant metastasis associated with decreased survival 2. Maxillary and frontal sinus primary tumor associated with decreased survival 3. Increased age associated with poor survival 1. No difference in OS between endoscopic and open surgery 2. No difference in 30- and 90-day mortality between endoscopic and open surgery 3. Endoscopic surgery has more unplanned readmissions 4. Open surgery with longer LOS (Continues) positive margins was not statistically better than no surgery at all

SNMM patients who underwent

2019 2

Systematic

reviewand meta analysis

endoscopic, open, or combined resection ( n = 510)

Guoet al. 1481

2022 4

Retrospective case series

SNMM patients at single institution

1. OS 2. RFS

with tissue available for analysis ( n = 45)

Elsamna et al. 365

1. OS 2. Margin status effect on OS

SNMM patients in NCDB 2010–2015 ( n = 446)

2021

4

Retrospective database study (NCDB)

Ganti et al. 366

2020 4

Retrospective database study (NCDB)

SNMM patients in NCDB 2004–2015 ( n = 1874)

OS

Lowet al. 1483

1. OS 2. DSS

SNMM patients in SEER database

2020 4

Retrospective database study (SEER)

1973–2015 ( n = 328)

Farber et al. 278

2019 4

Retrospective database study (NCDB)

SNMM patients in NCDB 2010–2015 ( n = 686)

1. OS 2. 30-day

mortality

3. 90-day

mortality 4. Readmission, LOS