xRead - Nasal Obstruction (September 2024) Full Articles

20426984, 0, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.23262, Wiley Online Library on [02/01/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

272

KUANetal.

TABLE XXIV.D.4 Evidence surrounding role of neck treatment in sinonasal mucosal melanoma.

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusion

RRR

1. Cumulative RRR, regardless of presenting N status, was 18% 2. Clinical N0 necks who did not have elective neck dissection hadRRR17% 3. END performed in 0.4% of cases, limiting ability to draw conclusions on effect of END Patient presentation with clinically involved regional nodes was associated with a < 4% 5-year OS 1. Consider SLNB if positivity will influence adjuvant therapy or clinical trial entry 2. If SLNB positive, completion neck dissection not recommended 3. If SLNB not technically feasible, consider END for appropriate levels only if it will influence adjuvant therapy Neck dissection not associated with improved 2-year OS

De Virgilio et al. 1486

2021

2

Systematic review

SNMM patients undergoing

treatment, with or without neck dissection ( n = 936)

Lowet al. 1483

2020 4

Retrospective database study (SEER)

SNMM patients in SEER database

OS

1973–2015 ( n = 328)

Evidence-based clinical recom mendations

Head and neck

Nenclares et al. 1514

2020 4

Expert

mucosal melanoma guidelines, reviewing retrospective publications ( n not specified)

consensus basedon retrospective data (UK National Guidelines)

Oliver et al. 1503

2019 4

Retrospective database study (NCDB)

All head and neck

1. OS 2. Factors

mucosal melanoma patients in NCDB 2004–2015 ( n = 1373)

associated with improved 2-yearOS

Torabi et al. 241

OS

1. No difference in OS between END and no END (42% vs. 43% 3-yearOS) 2. 23 ENDs performed

Head and neck

2019 4

Retrospective database study (NCDB)

mucosal melanoma patients with clinically negative necks in NCDB

2004–2015 ( n , SNMM = 275)

Amit et al. 1520

2017 4

Retrospective case series

SNMM patients at a single institution ( n = 198)

1. RRR 2. DSS

1. Regional recurrence 30% in those who underwent therapeutic neck dissection versus 17% who presented with cN0neck 2. Presence of regional lymph node metastasis not associated with OSorDSS

Lundet al. 1482 0% survival at 5 years with clinically positive regional nodes at presentation Abbreviations: DSS, disease-specific survival; NCDB, National Cancer DataBase; OS, overall survival; RRR, regional recurrence rate; SEER, Surveillance, Epidemiology, and End Results; SLNB, sentinel lymph node biopsy; SNMM, sinonasal mucosal melanoma. 2012 4 Retrospective case series SNMM patients at a single institution ( n = 115) 1. OS 2. DSS