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277

ICAR SINONASAL TUMORS

TABLE XXV.1 Evidence surrounding World Health Organization subtypes in nasopharyngeal carcinoma.

Clinical endpoints Conclusion

Study

Year LOE Study design Study groups

Stepan et al. 1733

OS

KSCCC had worse OS than DNKSCC (aHR 0.67, 95% CI: 0.60–0.74, p < 0.001) and UNKSCC (aHR 0.55, 95% CI: 0.48–0.63, p < 0.001) KSCC (males 41.9% and females 41.5%) had worse RS than DNKSCC (males 63.1% and females 63.4%) and UNKSCC (males 65.8% and females 70.1%) 1. 3-year DSS rates were KSCC (61.76%), NKSCC (79.57%), and BSCC (77.55%) 2. 5-year DSS rates were KSCC (55.07%), NKSCC (72.09%), and BSCC (74.03%) 3. After adjusting these covariates by using multivariate analysis, patients with KSCC had a worse prognosis than those with NKSCC (HR 0.6, 95% CI: 0.53–0.67, p < 0.001) or BSCC (HR 0.51, 95% CI: 0.31–0.86, p = 0.011) 1. BSCC had fair short-term but poor long-term survival 2. 1-year DSS: BSCC 87.7%, NKSCC 90.8%, KSCC 67.1% ( p < 0.0001) 3. 5-year DSS: BSCC 60.7%, NKSCC 58.2%, KSCC 40.7% ( p < 0.0001) 4. 10-year DSS: BSCC 29.8%, NKSCC 38.2%, KSCC 27.9% ( p < 0.0001) 1. 0–5 years: DNKSCC had worse DSS than UNKSCC 2. > 5 years: DNKSCC had comparable DSS with UNKSCC 3. 0–3 years: KSCC had worse DSS than UNKSCC 4. > 3 years: KSCC had comparable DSS with UNKSCC 5. For the entire cohort, KSCC had poorer DSS than UNKSCC (HR 2.323, 95% CI: 1.636–3.297, p < 0.001) and UNKSCC (HR 1.435, 95% CI: 0.945–2.111, p = 0.067) 1. KSCC had worse OS than UNKSCC, but there were no OS differences between DNKSCC and UNKSCC 2. The 5-year DSS and OS of all patients treated between 1990 and 1999 were 58% and 49%, and those between 2000 and 2009 were 66% and 63%, respectively 3. KSCC had worse OS than UNKSCC (aHR 1.84, 95% CI: 1.13–2.99, p = 0.01),

9995 (1661 UNKSCC, 2370 DNKSCC, 5964 KSCC) 6284 (1413 UNKSCC, 968 DNKSCC, 2815 KSCC) 4085 (2203 NKSCC, 1929 KSCC, 53 BSCC)

2021 4

Retrospective database study (NCDB) Retrospective database study (SEER) Retrospective database study (SEER)

Argirion

2020 4

5-yearRS

et al. 1605

Panet al. 1593

DSS

2020 4

Unsal et al. 1607

2019 4

Retrospective database study (SEER)

82BSCC

DSS

Wuet al. 1594

DSS

2845 (778 UNKSCC, 849 DNKSCC, 1218 KSCC)

2019 4

Retrospective database study (SEER)

Ruuskanen et al. 1604

2018 4

Retrospective database study (Finnish Cancer Registry database)

207 (132 UNKSCC, 31 DNKSCC, 42 KSCC)

1. OS 2. DSS

but there were no OS differences between DNKSCC and UNKSCC (aHR 1.60, 95% CI: 0.89–2.87, p = 0.12) (Continues)