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ICAR SINONASAL TUMORS

TABLE XXV.2 Evidence surrounding EBV DNA in NPC.

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusion

Diagnostic role of circulating EBV DNA Liuet al. 1628 2021 1

Systematic

87 studies, 23,474

Pooled

EBV DNA detection has higher diagnostic accuracy in NPC

reviewand meta analysis

subjects (8382 NPCs, 15,089 controls)

sensitivity 0.76, specificity 0.96, positive likelihood 14.66, negative likelihood 0.19 sensitivity 0.69, specificity 0.84, positive likelihood 4.81, negative likelihood 0.25 sensitivity 0.75, specificity 0.87, positive likelihood 6.98, negative likelihood 0.18 sensitivity 0.73, specificity 0.89, positive likelihood 8.84, negative likelihood 0.19 sensitivity 89.1%, specificity 85.0%, positive likelihood 7.118, negative likelihood 0.122

Sunet al. 1627

EBV DNA could be a useful tumor marker for NPC diagnosis

Pooled

10 studies, 2520

2014 1

Systematic

subjects (617 NPCs, 1903 controls)

reviewand meta analysis

Songand

2013 1

Systematic

27 studies, 4486

Pooled

EBV DNA has high sensitivity and specificity in the diagnosis of NPC

Yang 1626

reviewand meta analysis

subjects (1554 NPCs, 2932 controls)

Hanet al. 1625

EBV DNA detection in plasma or serum has high sensitivity and specificity in the diagnosis of NPC

Pooled

2012 1

Systematic review

18 studies, 4133

subjects (1492 NPCs, 2641 controls)

Liuet al. 1624

2011 1

Systematic

15 studies, 2393

Pooled

The detection of EBV DNA for the diagnosis of NPC has good sensitivity and specificity and might be helpful for the screening of NPC

reviewand meta analysis

subjects (1140 NPCs, 1253 controls)

1. Treatment strategy guidance of circulating EBV DNA 2-1 Aids in the treatment outcome prediction and risk grouping Quet al. 1633 2020 1 Systematic reviewand meta analysis

Pre-, mid-, and post-EBV DNA levels have prognostic impact in NPC patients, particularly post-DNA levels

22 studies, 8128 NPCs 1. OS 2. PFS 3. DMFS

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