xRead - Nasal Obstruction (September 2024) Full Articles

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286

KUANetal.

TABLE XXV.4 (Continued)

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusion

Vlantis et al. 1749

1. OS 2. DFS

1. 2-year OS and DFS were 100% and 90%, respectively 2. Postoperative complication rate was 55.6% ENPG + CRT group had better OS than CRT alone group

2017 4

Retrospective case series

Recurrent T1–2 NPC who underwent ENPG( n = 18) Recurrent T1–4 NPC who underwent: (1) ENPG + CRT ( n = 36) and (2) CRT ( n = 26)

Wenget al. 1750

2017 4

Retrospective case series

1. OS 2. DFS

Wonget al. 1751

1. 2-year OS, DFS, and DSS were 66.7%, 40%, and 73%, respectively 2. No severe operative complications were reported Compared with IMRT, salvage ENPG may be more effective for maximizing survival (77.1% vs. 55.5%) and decreasing complications (12.5% vs. 65.3%). ENPG and IMRT are associated with an improved OS and DMFS in patients with recurrent NPC compared to two-dimensional conventional RT in early recurrence 1. 5-year OS, DSS, and DFS were 75.1%, 80.9%, and 58.1%, respectively 2. No major complications were reported 1. 2-year OS and DFS were 100% and 69.2%, respectively 2. Overall minor complication rate was 52.6% 3. No major complications 1. 2-year OS, LRFS, and PFS were 84.2%, 86.3%, and 82.6%, respectively 2. No severe complications were observed 1. 2-year OS and DFS were 59.4 and 57.6%, respectively 2. Three patients had nasopharynx osteonecrosis and one patient developed hypoglossal nerve dysfunction

1. OS 2. DFS 3. DSS

2017 4

Retrospective case series

rT3–4 NPC who

underwent ENPG ( n = 15)

Youet al. 1752

2015 4

Retrospective

rT1–3 NPC who underwent: (1)

OS

case–control

ENPG( n = 72) and (2) IMRT( n = 72)

Zouet al. 1666

1. OS 2. DMFS

2015 4

Retrospective case series

rT1–4 NPC who underwent: (1)

ENPG( n = 92), (2) IMRT( n = 218), and (3) 2DRT( n = 100)

Castelnuovo et al. 1664

2013 4

Retrospective case series

rT1–4 NPC who

1. OS 2. DFS 3. DSS

underwent ENPG

Hoet al. 1753

1. OS 2. DFS

2012 4

Retrospective case series

rT1–3 NPC who

underwent ENPG ( n = 13)

Chenet al. 1754

2009 4

Retrospective case series

rT1–3 NPC who

1. OS 2. LRFS 3. PFS

underwent ENPG ( n = 37)

Koet al. 1755

1. OS 2. DFS

2009 4

Retrospective case series

rT1–3 NPC who

underwent ENPG ( n = 28)

Abbreviations: DFS, disease-free survival; DSS, disease-specific survival; ENPG, endoscopic nasopharyngectomy; IMRT, intensity modulated radiation therapy; LDRT, low-dose radiotherapy; LPFS, local progression-free survival; LRC, local–regional control; OS, overall survival; PFS, progression-free survival.