xRead - Nasal Obstruction (September 2024) Full Articles

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ICAR SINONASAL TUMORS

TABLE XXVI.3 (Continued)

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusion

Guoet al. 1850

1. OS 2. PFS

There may be benefit to PFS with oral nitrosourea, but no difference in OS

2008 4

Retrospective case series

57 patients with Stage I and II disease treated with combined CRT (CHOP— cyclophosphamide, Adriamycin, vincristine, prednisone), six patients with stage III or IV who underwent CHOP who underwent RT if remission achieved 53 patients with stage IE/IIE disease treated with CHOP nasal/nasopharynx, 14upper aerodigestive) treated with CEOP-B (cyclophosphamide, epirubicin, vincristine, prednisone) 26 had chemotherapy alone, 17 had CRT ENKTLs of any site treated with anthracycline chemotherapy ± RT, nonanthracycline chemotherapy ± RT, RT alone, or supportive care only 90 patients with chemotherapy followed by RT (median 45 Gy) 43 patients with ENKTL (29

Wanget al. 1854

2007 4

Retrospective case series

1. OS 2. PFS

1. 2-year OS was 75.6% and 2-year PFS was 61.8% 2. Chemotherapy followed by RT produced suboptimal outcomes

Kimet al. 1903

1. Overall response was 67.4% 2. Local relapse higher in

1. OS 2. Treatment response

2006 4

Retrospective case series

chemotherapy-only group, but RT did not improve survival

3. CEOP-B has limited role in ENKTL treatment

Lee et al. 1852

2005 4

Retrospective case series

1. OS 2. Treatment response

Higher survival in upper aerodigestive disease versus other location (54% vs. 20%)

Kimet al. 1851

1. OS 2. DSS

5-year OS was 37%, DSS 37% for ENKTL, results not specified by treatment type

2004 4

Retrospective case series

84 patients with sinonasal

lymphoma (19 B cell, 27 T cell, 34

ENKTL); 45 patients underwent RT alone (median 50.4 Gy), chemotherapy was left to physician discretion

(Continues)