xRead - Nasal Obstruction (September 2024) Full Articles

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351

ICAR SINONASAL TUMORS

TABLE XXXII.1 Evidence surrounding general QOL after treatment for SNM.

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusion

1. In the focus groups, the top categories mentioned were sight, lost work, hobbies, crusting, memory, family relations, energy, headache, smell, and social relations 2. Of the nonphysical domains, social and financial domains were referenced more in the open surgery group and spiritual, family, emotional, and cognitive domains more in the endoscopic group 3. Of the physical domains, visual was referenced more in the open group and nasal and endocrine more in the endoscopic group 1. 15% of patients had HADS subscale scores > 11, indicating severe anxiety or depression 2. On the FACT-NP, physical well-being had the highest median score and emotional/functional well-being had the lowest 3. Advanced T stage, single status, and worse social support were associated with higher HADS scores, and worse social support was associated with worse FACT-NP scores 1. General QOL on the SF-36 was similar between patients with skull base meningiomas and convexity meningiomas as well as controls at median of 9-year follow-up 2. Patients treated with RT had lower QOL in bodily pain and vitality domains than patients treated with surgery 3. 44% of skull base meningioma patients had deficits in at least one domain of neurocognitive functioning 1. Mental health disorders increased postdiagnosis versus prediagnosis 2. Patients with mental health disorders were more likely to be female and have a smoking history 3. RT was more strongly associated with development of a mental health disorder than surgery or chemotherapy

1. Postoperative physical complaints 2. Physical and nonphysical QOL domains 3. Themes identified from focus groups

138 patients

deAlmeida et al. 2070

2012 1

Retrospective cohort and systematic review

undergoing endoscopic or open skull base surgery

for anterior or central lesions

Phillips et al. 2103 2021 3

Retrospective cohort

181 patients treated for SNM with various modalities (surgery, chemotherapy, and/orRT)

QOL as measured by theHADS and FACT-NP scores

Fisher et al. 2118

1. QOLas

1. 89 patients with skull base meningiomas 2. 84 patients with convexity meningiomas 3. 65 caregivers (controls)

2021 3

Multicenter cross sectional study

measured by the SF-36 and EORTC QLQ-BN20 questionnaires 2. Neurocognitive functioning

Lee et al. 2119

2020 3

Retrospective database study

6760 patients with

Frequency of

sinonasal/skull base cancer in the MarketScan database

mental health disorders pre and postdiagnosis

(MarketScan database)

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