xRead - Nasal Obstruction (September 2024) Full Articles

20426984, 0, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.23262, Wiley Online Library on [02/01/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

363

ICAR SINONASAL TUMORS

TABLE XXXII.3 (Continued)

Clinical endpoints

Study

Year LOE Study design Study groups

Conclusion

Huang et al. 2161

1. 36% of patients required surgery due to complications 2. Most common treatment indications were blowout bleeding, CNS infection, pain, or recurrent bloody discharge 3. The majority of patients received free vastus lateralis flap reconstruction. 4. Surgery was effective in managing complications in all patients There were 14 grade 3 + toxicities, including ocular toxicity, sinonasal cutaneous fistula, facial cellulitis, flap dehiscence requiring revision, and trismus complications (three with otologic signs requiring myringotomy tubes) 3. 85% of patients had clinical improvement after HBO, seen as healing tissue over bone 4. Five patients required surgical reconstruction during 2-year follow-up 1. Frequent symptoms included foul odor, headache, and epistaxis 2. CT characteristically showed extensive bone destruction 3. Nine patients received surgery 1. Patients received a mean number of 26 HBO sessions 2. Four patients developed HBO

2018 4

Retrospective case series

162 patients with skull baseORN

1. Treatment indications 2. Treatment modality 3. Treatment efficacy

Russo et al. 528

2016 4

Retrospective case series

54 patients with stage 3/4 sinonasal SCC undergoing proton beam RT with or without prior surgical resection 21 patients receiving

Treatment toxicities

Gavriel et al. 2158

1. Response to treatment 2. Further management required

2016 4

Retrospective case series

treatment with HBO for maxillary bone ORN that occurred after photon RT for tumor

Huang et al. 2156

2006 4

Retrospective case series

15 patients with skull base ORN after RT forNPC

1. Symptoms 2. Examand imaging findings 3. Treatment options

and six patients received conservative treatment, including nasal rinsing, antibiotics, and HBO

Abbreviations: ACC, adenoid cystic carcinoma; AE, adverse events; ASBQ, Anterior Skull Base Questionnaire; CTCAE, Common Terminology Criteria for Adverse Events; FACT-HN, Functional Assessment of Cancer Therapy: Head and Neck; HBO, hyperbaric oxygen; MDASI, MD Anderson Symptom Inventory; ORN, osteoradionecrosis; RIBI, radiation-induced brain injury; RT, radiation therapy; SCC, squamous cell carcinoma; SNM, sinonasal malignancy; XeQoLS, Xerostomia QOLScale.