xRead - Nasal Obstruction (September 2024) Full Articles

20426984, 2021, 3, Downloaded from https://onlinelibrary.wiley.com/doi/10.1002/alr.22741 by Stanford University, Wiley Online Library on [01/07/2024]. See the Terms and Conditions (https://onlinelibrary.wiley.com/terms-and-conditions) on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License

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Orlandi et al.

TABLE V-6 Evidence for the definition of acute exacerbation of chronic rhinosinusitis Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Kuiper 212 2018 3 Prospective cohort study, survey based Patient with CRS Survey responses every 4 months with self-reported exacerbations Three definitions of AECRS operationalized and assessed The most sensitive definition of AECRS was a worsening in sinonasal symptoms ≥ 1week in duration. The definition with the highest positive predictive value of AECRS was a worsening in sinonasal symptoms ≥ 1 week and green/yellow discharge. Orlandi 1 2016 4 Literature Review (AECRS section)

Wu 210 2019 4 Literature Review N/A Definition of AECRS AECRS sudden worsening of symptoms in a patient previously diagnosed with CRS, with a return to baseline symptoms after treatment.

Consensus definition and diagnostic criterion are still lacking. N/A Definition of AECRS AECRS includes worsening nasal blockage, congestion or stuffiness, nasal discharge or

postnasal drip, facial pain, pressure or headache, and reduction in sense of smell. AECRS may be accompanied by purulence,

crusting, edema or polyps on endoscopic exam.