xRead - Nasal Obstruction (September 2024) Full Articles

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294

International consensus statement on rhinosinusitis

Cure rates with antibiotics were higher when fluid level or total opacification was found on CT Confirmed prior report 403

When clinical failure was defined as a lack of full recovery, antibiotics decreased risk of failure. Amoxicillin + clavulanate had

Young 407 2008 1 Meta-analysis of RCTs Antibiotics vs placebo for ARS Symptom resolution 15 patients need to be treated before 1 benefits from antibiotics

Antibiotic compared to placebo relieves symptoms in a higher

proportion of ARS patients, only earlier in the course of treatment

Five per 100 will cure faster between 7 and 14 days if they receive antibiotics

27% who received antibiotics vs 15% who received placebo experienced adverse events Falagas 406 2008 1 Meta-analysis of RCTs Short-term therapy (up to 7 days) for ARS Improvement of symptoms

Purulent secretion resolved faster with antibiotics

significantly more drop-outs due to adverse effects than

cephalosporins and macrolides

No difference between short- and long-term courses of antibiotics

TABLE VII-9 Evidence for antibiotic therapy in ARS Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Lemiengre 318 2018 1 Systematic review of RCTs (15 total studies) based on symptoms Cure when diagnosed radiologically

Cure or improvement at days 3, 7, and 10 post

antibiotic or placebo

Clinical symptoms at 7 to 15days Drop-outs due to

medication side efects

Adverse events

Antibiotic vs placebo for ARS Cure when diagnosed Antibiotic vs placebo for ARS symptoms lasting for 7 or moredays

Antibiotic vs placebo for ARS Symptom resolution Longer- term therapy for ARS (9 or more days)

Antibiotic vs placebo for ARS

Differing classes of antibiotics

Burgstaller 404 2016 1 Systematic review of RCTs (only 6 met criteria)

Lemiengre 403 2012 1 Systematic review of RCTs (10 studies)

Saloranta 405 2014 1 Systematic review of RCTs and meta-analysis

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