xRead - Nasal Obstruction (September 2024) Full Articles

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Orlandi et al.

No differences seen in any outcomes

Headache, facial pain, nasal congestion, and dizziness improved with steroid

TABLE VII-12 Evidence for systemic corticosteroids in ARS Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Venekamp 430 2014 1 Meta-analysis of 5 RCTs (n = 1193) Systemic corticosteroid Placebo Symptom improvement, time to resolution, bacteriological cure/relapse, adverse events Oral corticosteroids are ineffective as monotherapy; oral corticosteroids may be beneficial as adjunct to antibiotics

Oral corticosteroids may help in short term relief,

particularly facial pain, but

effect diminishes by 14 days

pain/pressure and other symptoms

Reduction in symptom severity by day 6

Regression of clinical symptoms or

radiologic signs by day 14

Resolution of facial

Ratau 429 2004 2 RCT (n = 42) Amoxicillin/clavulanate 625 mg TIDplus: Betamethasone 1 mg daily (n = 21) Placebo daily (n = 21)

Venekamp 428 2012 2 RCT (n = 185) Prednisolone 30 mg daily (n = 93) Placebo (n = 92)

Methylprednisolone 8 mg TID (n = 208) Placebo (n = 209)

Gehanno 427 2000 2 RCT (n = 417) Amoxicillin/clavulanate 500 mg TIDplus: