xRead - Nasal Obstruction (September 2024) Full Articles

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International consensus statement on rhinosinusitis

Koch 455 2016 1 Systematic review Herbal medicine may be effective in ARS but more research is necessary Guo 456 2006 1 Systematic review ofRCTs Some evidence for benefit with bromelain and Sinupret R inARS

Pfaar 459 2012 3 DBPCT Patients with ARS treated with 8 days of amoxicillin and concomitantly with 15 days of: Intranasal Cyclamen europaeum extract Placebo spray reach significance with total symptom scores Zalmanovici 457 2018 1 Systematic review No data to support use of Cyclamen europaeum extract for ARS Symptom scores Endoscopic assessment Cylamen significantly reduced facial pain and endoscopic scores but failed to

Every result was statistically significant in favor of Pelargonium sidoides

Cineole was more effective than the combination herbal components, but no placebo group. Cyclamen was more effective at

radiologic improvement but not superior to placebo for symptom severity

Symptoms scores Statistically significant improvement in favor of herbal treatment

Fokkens 26 2020 5 Guidelines Some herbal supplements may have significant impact on symptoms

TABLE VII-17 Evidence for herbal treatments in ARS Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Gabrielian 452 2002 3 DB parallel-group clinical study

endoscopic

assessment

Sinus severity score.

Radiologic changes Ability to work Clinical and

Symptom severity

Radiologic changes

Ponikau 458 2012 3 DBPCT Patients with ARS treated for 7 days with: Intranasal lyophilized, reconstituted Cyclamen europeaum extract (Cyclamen) Placebo spray

Bachert 453 2009 3 DBRCT Patients ARS treated with: Pelargonium sidoides drops Placebo

Patients with acute upper respiratory tract infections with subgroup analysis of ARS were treated for 5 days with: Andrographis paniculate SHA-10/ Eleutherococcus senticosus fixed combination extract Placebo

Patients with ARS and viral RS randomized to: Cineole

Combination of 5 different herbal components

Tesche 454 2008 3 DBRCT; no placebo control