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314

International consensus statement on rhinosinusitis

SNOT-20 and RSI scores in

RARS group comparable to the CRS group.

Significant improvement in SNOT-22 and RSDI scores. Decreased antibiotic and decongestant use.

Significant reduction in CCS and RSDI domain scores. Reduction in sinus

medications use based on CSS scores.

TABLE VIII-6 Evidence for ESS in the management of RARS Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Sikand 511 2018 2 Unblinded RCT In-office BSD and MedMgt In-office sham procedure andMedMgt CSS, RSDI, recurrent infections Significant improvement in CSS and RSDI scores. Reduced mean number of sinus infections. Sohn 509 2018 3 Case-control ESS in RARS, CRSsNP, andCRSwNP SNOT-20 Significant improvement in SNOT-20 scores.

Steele 508 2016 3 Case-control ESS in RARS and CRS SF-6D Significant improvement in health utility values. Steele 248 2016 3 Case-control ESS in RARS and CRS SNOT-22, RSDI, antibiotic utilization,

Costa 208 2015 3 Case-control ESS vs MedMgt in RARS SNOT-22 Greater symptomatic improvement (SNOT-22 scores) compared to MedMgt.

Bhandarkar 507 2011 3 Case-control ESS in RARS and CRS Antibiotic utilization 61.2% reduction in antibiotic utilization in RARS patients.

Bhattacharyya 506 2006 4 Case series ESS inRARS RSI Significant decrease in RSI scores. Decreased antihistamine use,

workdays missed, and acute episodes.

Levine 512 2013 3 Case-control BSD in RARS and CRS SNOT-20, RSI Mean improvement in

decongestant use

Poetker 501 2008 3 Case-control ESS in RARS and CRS CSS, RSDI; Endoscopic exam, CTscores