xRead - Nasal Obstruction (September 2024) Full Articles

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KUANetal.

TABLE I.1 (Continued)

Treatment modality

Category

Histopathology

AGE Recommendation Specific indications

ONB

IC Sx

C Option

Locally advanced disease Primary modality Endoscopic surgery option

Neuroendocrine or neuroectodermal tumors

C a

Recommendation a

aRT

C Option

Hyams grades III/IV Kadish stages C/D Positive margins Hyams grades III/IV Kadish stages C/D

END/ENI

C Option

SNUC

IC

B

Recommendation IC followed by CRT for responders IC followed by salvage surgery for nonresponders

SNEC

IC

C Recommendation Locally advanced disease High-grade tumors

Sx

Primary modality

aRT

SNMM

Sx

C Recommendation Primary modality

aRT

C Option

Local control, but no OS benefit Locally advanced disease Metastatic disease Regional control, but no OS benefit Advanced-stage disease Advanced-stage disease Consider for stage II patients with bulky nodal disease Option to limit RT to lower neck lymphatics if no radiographic nodal metastases or if unilateral nodal disease CHOP or CHOP-like therapy Symptomatic (e.g., cranial nerve palsies) Bulky disease Advanced-stage disease Early-stage disease IMRT standard of care

Immunotherapy C Option

END/ENI

C Option

Nasopharyngeal malignancies

NPC

IC

A Strong

recommendation

dCRT

A Strong

recommendation

RT

A Strong

recommendation

END/ENI

B

Option

Lymphoma

BCL

C

B

Recommendation Primary modality

RT

B

Option

Immunotherapy B

Recommendation Rituximab

ENKTL

C

C Recommendation Primary modality LRC benefits

RT C Recommendation Abbreviations: AGE, aggregate grade of evidence; aRT, adjuvant RT; dCRT, definitive CRT; END/ENI, elective neck dissection/irradiation; IC, induction

chemotherapy; Sx, surgery. a Abstracted from ICSB 2019. 5 b All surgical treatment is predicated on achieving negative margins for curative intent, with exception of some cases of ACC.