xRead - Nasal Obstruction (September 2024) Full Articles

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International consensus statement on rhinosinusitis

TABLE IX-8 Evidence for vitamin D deficiency as a contributing factor for CRSsNP Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Wang 713 2019 4 Retrospective case-control 42Control 25CRSwNP 21CRSsNP Serum 25VD3 SNOT22 LMscore No difference in serum 25VD3 between CRSsNP and controls. Habibi 725 2019 4 Case-control 50Control 35CRSsNP 32CRSwNP Serum 25VD3 Serum 25VD3 is lower in CRSsNP compared to controls. Christensen 724 2017 4 Case-control 13Control 8CRSsNP 10CRSwNP Sinonasal Vitamin D Receptor (VDR) gene expression level Sinonasal CYP2R1, CYP27B1, CYP24A1 gene expression levels Nasal symptom score (NSS) No difference in VDR expression between CRSsNP and controls. CYP27B1 gene expression lower in CRSsNP compared to controls. CYP24A1 upregulated in CRSsNP compared to controls. Konstantinidis 714 2017 4 Case-control 32Control 30CRSsNP 32CRSwNP 31CFsNP 27CFwNP Serum 25VD3 Lund-Kennedy score Lund-Mackay score No difference in serum 25VD3 levels between CRSsNP and Controls. 25VD3 inversely correlated with Lund-Kennedy and Lund-Mackay scores in CRSandCF. Schlosser 715 2016 4 Case-control 18Control 13CRSwNP 13CRSsNP 6AFRS Sinonasal 1 α hydroxylase level Sinonasal 1,25 VD3 SNOT22 Serum 1,25VD3 No difference in sinonasal 1 α hydroxylase and 1,25VD3 between CRSsNP and Controls. No difference in serum 1,25 VD3 between CRSsNP and controls. (Continues)