xRead - Nasal Obstruction (September 2024) Full Articles

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Orlandi et al.

Radiological changes can be widespread in patients with hypogammaglobulinemia. RS

symptoms do not resolve with IVIG, but early treatment may prevent chronic changes in sinus mucosa. Williams 956 1991 4 Case series Patients with primary hypogammaglob ulinemia; age 15-65; n = 17 Symptom scores pre- and post IVIG therapy Measured and corrected sinus washout return fluid IgG concentrations

High dose therapy with IVIG appears to be the treatment of choice in patients with sinopulmonary disease. Watts 932 1986 4 Case series Patients with common variable hypogammaglob ulinemia; age 11-53; n = 32 Pulmonary function tests chest radiographs pulmonary symptom questionnaire

The administration of increased amount of IVIG is of benefit in patients with chronic sinopulmonary disease.

Pulmonary function and chest radiograph scores remained stable while CVH patients received adequate therapy. Roifman 950 1985 4 Case series Patients with hypogammaglob ulinemia; age 7-49; n = 7 Serum IgG levels Clinical and radiographic (CT) evidence of RS PFTs Buckley 945 1972 4 Retrospective review Adult patients with chronic respiratory disease; n = 688

Poor clinical responses do not appear to be due to lack of penetration of antibodies to the required sites of action. The addition of antibiotics at high dosage may be a more economical therapeutic alternative to high dose IVIG therapy. Roifman 951 1988 4 Case series Patients with hypogammaglob ulinemia; age 7-50; n = 12 Serum IgG levels Sputum cultures Chest and sinus radiographs PFTs

Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Scadding 948 1994 4 Case series Adult patients with CRS or RARS; age 15-60; n = 74 Serum total IgG levels Serum IgG subclass levels Ig replacement therapy has been shown to be efficacious in the treatment of IgG3-deficient individuals. Snow 949 1993 4 Case series Patients with PID receiving IVIG therapy; age 17-70; n = 13 Sinonasal symptoms CTscores

Humoral immune surveillance may be important in the pathogenesis of chronic respiratory disease.

Serum immunoglobulin measurements

TABLE IX-18 (Continued)