xRead - Nasal Obstruction (September 2024) Full Articles

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408

International consensus statement on rhinosinusitis

(Continues)

TABLE IX-31 Evidence for CRSsNP management with macrolide antibiotics Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Huang 1118 2019 1 Meta-analysis CRSsNP or CRSwNP 7 studies TNSS, VAS, endoscopy score, CTscore Adding clarithromycin to INCS ± nasal saline irrigation may yield better results than INCS ± nasal saline irrigation alone. Seresirikachorn 1121 2019 1 Meta-analysis CRSsNP or CRSwNP 10 studies SNOT, symptom score, CT score, endoscopy score Favorable outcomes in patients with CRSsNP. A half dose of macrolides should be given for a duration of 24weeks.

Pynnonen 1117 2013 1 Meta-analysis of RCTs CRSsNP and CRSwNP. 3 RCT SNOT Insufficient evidence to recommend long-term macrolide therapy. Soler 1119 2013 1 Systematic review of RCTs and cohort studies CRSsNP or CRSwNP. 2RCTs

therapy is an option in

selected CRS patients.

Recommendation level: Option

Long-term macrolide

14 prospective observational studies

Cervin 1120 2014 1 Systematic review CRSsNP and CRSwNP. 2 RCTs 22 Open/cohort studies

1 case-control study