xRead - Nasal Obstruction (September 2024) Full Articles

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415

Orlandi et al.

(Continues)

volume mupirocin may be beneficial in recalcitrant S. aureus.

TABLE IX-33 Evidence for CRS management with topical antibiotics Study Year LOE Study Design Study Groups Clinical Endpoint Conclusions Head 1105 2016 - Cochrane systematic review No studies met inclusion criteria. No recommendation. Kim 1143 2016 1 Systematic Review and meta-analysis Topical mupirocin is an effective short-term treatment for recalcitrant staphylococcal CRS. Rudmik 1139 2015 1 Systematic review of RCTs with heterogeneity Routine use not recommended. High

Topical antibiotic therapy not recommended as first-line therapy, but

may be considered for recalcitrant CRS.

Use of topical antibiotics recommended against

due to lack of evidence. Nebulized antibiotics cannot be

Topical antibiotics may be effective, but further high-level studies are required.

topical antibiotic due to insufficient clinical research.

recommended due to lack of evidence.

Recommend against

Lee 1155 2014 1 Systematic review with

heterogeneity

Soler 1119 2013 1 Systematic review with

heterogeneity

Lim 1140 2008 1 Systematic review with

heterogeneity

Rudmik 1141 2013 1 Systematic review with

heterogeneity

Woodhouse 1156 2011 1 Systematic review of RCTs with

heterogeneity